A PORCINE GUT POLYPEPTIDE IDENTICAL TO THE PANCREATIC HORMONE PP (PANCREATIC-POLYPEPTIDE)

被引：11

作者：

CHEN, ZW

BERGMAN, T

OSTENSON, CG

HOOG, A

NASLUND, J

NORBERG, A

CARLQUIST, M

EFENDIC, S

MUTT, V

JORNVALL, H

机构：

[1] KAROLINSKA INST,DEPT MED BIOCHEM & BIOPHYS,S-17177 STOCKHOLM,SWEDEN

[2] KAROLINSKA HOSP,DEPT ENDOCRINOL & CLIN GENET,S-17176 STOCKHOLM,SWEDEN

[3] KAROLINSKA HOSP,DEPT ALCOHOL & DRUG ADDICT RES,S-17176 STOCKHOLM,SWEDEN

[4] KAROLINSKA HOSP,DEPT PATHOL,S-17176 STOCKHOLM,SWEDEN

[5] KARO BIO AB,S-14104 HUDDINGE,SWEDEN

来源：

FEBS LETTERS | 1994年 / 341卷 / 2-3期

关键词：

PANCREATIC HORMONE; PANCREATIC POLYPEPTIDE; PIG INTESTINE; RADIOIMMUNOASSAY; IMMUNOHISTOCHEMISTRY;

D O I：

10.1016/0014-5793(94)80464-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A peptide hormone has been isolated from porcine intestine. Its primary structure was found to consist of 36 amino acid residues in a sequence identical to that of the porcine pancreatic polypeptide, previously not isolated from intestines or a tissue other than pancreas. The gut polypeptide significantly suppresses glucose-induced insulin secretion in vitro. Using an immunohistochemical technique, we also identified cells in the porcine gastrointestinal tract that were immunoreactive with pancreatic polypeptide. The immunoreactivity disappeared after absorption with the isolated gut polypeptide or synthetic human pancreatic polypeptide.

引用

页码：239 / 243

页数：5

共 34 条

[1] DISTRIBUTION AND RELEASE OF HUMAN PANCREATIC POLYPEPTIDE
ADRIAN, TE
BLOOM, SR
BRYANT, MG
POLAK, JM
HEITZ, P
BARNES, AJ
[J]. GUT, 1976, 17 (12) : 940 - 944
[2] PANCREATIC SECRETORY TRYPSIN-INHIBITOR (PSTI) ISOLATED FROM PIG INTESTINE - INFLUENCE ON INSULIN AND SOMATOSTATIN RELEASE
AGERBERTH, B
OSTENSON, CG
EFENDIC, S
JORNVALL, H
[J]. FEBS LETTERS, 1991, 281 (1-2) : 227 - 230
[3] AMINO-ACID-SEQUENCE OF PR-39 - ISOLATION FROM PIG INTESTINE OF A NEW MEMBER OF THE FAMILY OF PROLINE-ARGININE-RICH ANTIBACTERIAL PEPTIDES
AGERBERTH, B
LEE, JY
BERGMAN, T
CARLQUIST, M
BOMAN, HG
MUTT, V
JORNVALL, H
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 202 (03): : 849 - 854
[4] ISOLATION AND CHARACTERIZATION OF PORCINE DIAZEPAM-BINDING INHIBITOR, A POLYPEPTIDE NOT ONLY OF CEREBRAL OCCURRENCE BUT ALSO COMMON IN INTESTINAL TISSUES AND WITH EFFECTS ON REGULATION OF INSULIN RELEASE
CHEN, ZW
AGERBERTH, B
GELL, K
ANDERSSON, M
MUTT, V
OSTENSON, CG
EFENDIC, S
BARROSSODERLING, J
PERSSON, B
JORNVALL, H
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 174 (02): : 239 - 245
[5] PURIFICATION OF PEPTIDE-HORMONES FROM CHINCHILLA PANCREAS BY CHEMICAL-ASSAY
ENG, J
KLEINMAN, WA
CHU, LS
[J]. PEPTIDES, 1990, 11 (04) : 683 - 685
[6] PRIMARY STRUCTURE OF PANCREATIC-POLYPEPTIDE FROM 4 SPECIES OF PERISSODACTYLA (PRZEWALSKI HORSE, ZEBRA, RHINO, TAPIR)
HENRY, JS
LANCE, VA
CONLON, JM
[J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1991, 84 (03) : 440 - 446
[7] COATED CHARCOAL IMMUNOASSAY OF INSULIN
HERBERT, V
LAU, KS
GOTTLIEB, CW
BLEICHER, SJ
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1965, 25 (10) : 1375 - +
[8] USE OF AVIDIN-BIOTIN-PEROXIDASE COMPLEX (ABC) IN IMMUNOPEROXIDASE TECHNIQUES - A COMPARISON BETWEEN ABC AND UNLABELED ANTIBODY (PAP) PROCEDURES
HSU, SM
RAINE, L
FANGER, H
[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1981, 29 (04) : 577 - 580
[9] CLASS-III HUMAN-LIVER ALCOHOL-DEHYDROGENASE - A NOVEL STRUCTURAL TYPE EQUIDISTANTLY RELATED TO THE CLASS-I AND CLASS-II ENZYMES
KAISER, R
HOLMQUIST, B
HEMPEL, J
VALLEE, BL
JORNVALL, H
[J]. BIOCHEMISTRY, 1988, 27 (04) : 1132 - 1140
[10] ISOLATION AND CHARACTERIZATION OF CHICKEN INSULIN
KIMMEL, JR
POLLOCK, HG
HAZELWOOD, RL
[J]. ENDOCRINOLOGY, 1968, 83 (06) : 1323 - +

← 1 2 3 4 →