PULMONARY-HYPERTENSION IN RATS .2. ROLE OF INTERLEUKIN-6

被引：54

作者：

MIYATA, M

SAKUMA, F

YOSHIMURA, A

ISHIKAWA, H

NISHIMAKI, T

KASUKAWA, R

机构：

[1] Department of Internal Medicine II, Pukushima Medical College, Fukushima

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 108卷 / 03期

关键词：

PULMONARY HYPERTENSION; INTERLEUKIN-6; BLOOD PLATELET;

D O I：

10.1159/000237166

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We administered human interleukin (IL)-6 to rats to examine whether it is implicated in the development of pulmonary hypertension (PH). The rats injected with IL-6 developed PH as determined by the weight ratio of the right ventricle to the left ventricle+septum. This ratio decreased with the appearance of IgG anti-human IL-6 antibody. Histologically we observed in the lungs, luminal occlusion of small muscular arteries, capillaries filled with fibrin thrombi, and localized hemorrhage. IL-6 increased the number of platelets, and the number of platelets correlated with the extent of PH. Thus, it seems likely that (IL-6) is involved in the formation of PH in this model.

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收藏

页码：287 / 291

页数：5

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