THE CHEMISTRY OF TAXANE DITERPENOIDS - THE PRESENT STATUS OF DEVELOPMENT OF TAXOL AS A NEW TYPE OF ANTITUMOR AGENT

被引:6
作者
MAKI, Y
SAKO, M
机构
关键词
TAXANE DITERPENOID; TAXININE; TAXOL; TRICYCLO [9,3,1,03,8] PENTADECANE; CHEMICAL STRUCTURE; SYNTHETIC APPROACH; ANTITUMOR ACTIVITY; MICROTUBULE ASSEMBLY PROMOTOR; CHEMICAL MODIFICATION;
D O I
10.5059/yukigoseikyokaishi.51.298
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The chemistry of taxane diterpenoids has a long history since about 1850. Recent advances in this field brought about the discovery of taxol and its derivatives (e.g. , taxotere) which are under the development as a new antitumor agent. This review describes the novel chemistry of the taxane diterpenoids including the historical matters in the initial period of researches. The present status in the chemical and biological studies of taxol is mentioned as one of highlights.
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页码:298 / 307
页数:10
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