FUNCTIONAL INTEGRITY OF BENZODIAZEPINE RECEPTORS OF THE GENICULOSTRIATE VISUAL PATHWAYS IN CREUTZFELDT-JAKOB DISEASE - A PHARMACOLOGICAL EVOKED-POTENTIAL STUDY

被引：11

作者：

AGUGLIA, U ^{[1
]}

OLIVERI, RL ^{[1
]}

GAMBARDELLA, A ^{[1
]}

QUATTRONE, A ^{[1
]}

机构：

[1] UNIV REGGIO CALABRIA CATANZARO,SCH MED,INST NEUROL SCI,CALABRIA,ITALY

来源：

JOURNAL OF NEUROLOGY | 1993年 / 240卷 / 01期

关键词：

CREUTZFELDT-JAKOB DISEASE; DIAZEPAM; FLASH-EVOKED VISUAL POTENTIALS; FLUMAZENIL; GAMMA-AMINOBUTYRIC ACID;

D O I：

10.1007/BF00838442

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We evaluated the effects of flumazenil (FMZ), a high-affinity benzodiazepine receptor antagonist, on flash-evoked visual potentials (FEPs) in a patient with Creutzfeldt-Jacob disease (CJD). FEPs were recorded in three different consecutive sessions: (1) basal condition, without any pharmacological treatment; (2) 3.5 min after i.v. administration of 5 mg FMZ; (3) 1 min after i.v. administration of 10 mg diazepam (DZP). FMZ provoked a marked increase in the amplitude as well as evident shortening of the latency of early FEP components. DZP reversed these effects. These results are in agreement with our previous findings of anatomical and functional integrity of the geniculo-striate pathways in human CJD and demonstrate functional integrity of benzodiazepine receptors in this visual system in CJD.

引用

页码：25 / 27

页数：3

共 16 条

[1] SENSORY EVOKED-POTENTIALS IN CREUTZFELDT-JAKOB DISEASE [J].

AGUGLIA, U ;

FARNARIER, G ;

REGIS, H ;

OLIVERI, RL ;

QUATTRONE, A .

EUROPEAN NEUROLOGY, 1990, 30 (03) :157-161

[2] DIFFERENT SUSCEPTIBILITIES OF THE GENICULATE AND EXTRAGENICULATE VISUAL PATHWAYS TO HUMAN CREUTZFELDT-JAKOB DISEASE (A COMBINED NEUROPHYSIOLOGICAL-NEUROPATHOLOGICAL STUDY) [J].

AGUGLIA, U ;

GAMBARELLI, D ;

FARNARIER, G ;

QUATTRONE, A .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1991, 78 (06) :413-423

[3] BENZODIAZEPINE AND GABA RECEPTORS IN THE RAT RETINA - EFFECT OF LIGHT AND DARK-ADAPTATION [J].

BIGGIO, G ;

GUARNERI, P ;

CORDA, MG .

BRAIN RESEARCH, 1981, 216 (01) :210-214

[4] CREUTZFELDT-JAKOB DISEASE - CLINICAL ANALYSIS OF A CONSECUTIVE SERIES OF 230 NEUROPATHOLOGICALLY VERIFIED CASES [J].

BROWN, P ;

CATHALA, F ;

CASTAIGNE, P ;

GAJDUSEK, DC .

ANNALS OF NEUROLOGY, 1986, 20 (05) :597-602

[5]

BURKE DA, 1988, LANCET, V1, P505

[6]

HAEFELY W, 1983, BENZODIAZEPINE RECOG, P73

[7]

HENDRY SHC, 1990, J NEUROSCI, V10, P2438

[8] PHARMACOKINETICS AND CLINICAL USE OF FLUMAZENIL (RO 15-1788) [J].

KLOTZ, U ;

KANTO, J .

CLINICAL PHARMACOKINETICS, 1988, 14 (01) :1-12

[9] INTRACORTICAL GENERATORS OF THE FLASH VEP IN MONKEYS [J].

KRAUT, MA ;

AREZZO, JC ;

VAUGHAN, HG .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1985, 62 (04) :300-312

[10] INHIBITORY PROCESSES IN THE FLASH EVOKED-POTENTIAL OF THE MONKEY [J].

KRAUT, MA ;

AREZZO, JC ;

VAUGHAN, HG .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1990, 76 (05) :440-452

← 1 2 →