RECENT PROGRESS IN BONE INDUCTION BY OSTEOGENIN AND BONE MORPHOGENETIC PROTEINS - CHALLENGES FOR BIOMECHANICAL AND TISSUE ENGINEERING

被引：27

作者：

REDDI, AH ^{[1
]}

CUNNINGHAM, NS ^{[1
]}

机构：

[1] NIDR,BONE CELL BIOL SECT,BETHESDA,MD 20892

来源：

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 1991年 / 113卷 / 02期

关键词：

D O I：

10.1115/1.2891233

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Implantation of demineralized bone matrix results in local bone induction. Bone induction is a sequential biological chain reaction that consists of chemotaxis and proliferation of mesenchymal cells and differentiation of bone. Osteogenin, a bone morphogenetic protein has been purified and the amino acid sequence determined. Recently a family of bone morphogenetic proteins have been cloned and expressed by recombinant DNA technology. The availability of growth and morphogenetic factors will permit the rational design of new bone. The challenge for the biomechanical engineer is to attain mechanically optimal and functionally adaptive new bone for various skeletal prostheses. We are on the threshold for fabrication of new bone based on sound architectural design principles of tissue engineering based on cellular and molecular biology of growth and differentiation factors.

引用

页码：189 / 190

页数：2

共 15 条

[1]

LUYTEN FP, 1989, J BIOL CHEM, V264, P13377

[2] COLLABORATION BETWEEN COLLAGENOUS MATRIX AND OSTEOGENIN IS REQUIRED FOR BONE INDUCTION [J].