HOW DOES CISPLATIN ALTER DNA-STRUCTURE - A MOLECULAR MECHANICS STUDY ON DOUBLE-STRANDED OLIGONUCLEOTIDES

被引：41

作者：

KOZELKA, J

CHOTTARD, JC

机构：

[1] Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Unité associée au CNRS no. 400, Université René Descartes, 75270 Paris Cedex 06

来源：

BIOPHYSICAL CHEMISTRY | 1990年 / 35卷 / 2-3期

关键词：

Antitumor drug; Cisplatin; DNA structure; Molecular mechanics;

D O I：

10.1016/0301-4622(90)80006-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular models for two double-stranded decanucleotides, d(GCCG*G*ATCGC)-d(GCGATCCGGC) (1) and d(GCTG*G*ATCGC)-d(GCGATCCAGC) (2), with the G* guanines cross-linked by a cis-Pt(NH3)2 moiety, were calculated using molecular mechanics. Nine models for 1 and eight models for 2 are reported; in all of them, the double helix is kinked by approx. 60° towards the major groove and slightly unwound. The model building has been guided by comparison with the NMR data available for duplex 1. The influence of the base at the 5′-side of the coordinated G* G* dinucleotide is discussed. © 1990.

引用

页码：165 / 178

页数：14

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