DEMONSTRATION BY INSITU HYBRIDIZATION OF THE PROOPIOMELANOCORTIN GENE IN THE RAT-HEART

被引：17

作者：

FORMAN, LJ

BAGASRA, O

机构：

[1] UNIV MED & DENT NEW JERSEY,SCH OSTEOPATH MED,DEPT MED,CAMDEN,NJ 08103

[2] TEMPLE UNIV,ST CHRISTOPHERS HOSP CHILDREN,SCH MED,DEPT PEDIAT,PHILADELPHIA,PA 19034

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 28卷 / 03期

关键词：

PROOPIOMELANOCORTIN GENE; MESSENGER RNA; BETA-ENDORPHIN; RAT HEART; INSITU HYBRIDIZATION;

D O I：

10.1016/0361-9230(92)90045-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A biotinylated oligonucleotide probe was used to demonstrate the presence in the heart of the portion of the proopiomelanocortin messenger RNA which contains the sequence for beta-endorphin. The probe indicated the presence of beta-endorphin messenger RNA in cardiac tissue and specifically in the cardiac muscle cell. The probe also confirmed the well-documented presence of messenger RNA for beta-endorphin in the anterior and neurointermediate lobes of the pituitary. These findings indicate that in addition to the pituitary, beta-endorphin is produced in situ in the heart.

引用

页码：441 / 445

页数：5

共 39 条

[21] A DIURNAL RHYTHM IN PROOPIOMELANOCORTIN MESSENGER-RIBONUCLEIC-ACID THAT VARIES CONCOMITANTLY WITH THE CONTENT AND SECRETION OF BETA-ENDORPHIN IN THE INTERMEDIATE LOBE OF THE RAT PITUITARY [J].