ANTISENSE OLIGONUCLEOTIDE ELIMINATES INVIVO EXPRESSION OF C-FOS IN MAMMALIAN BRAIN

被引：145

作者：

CHIASSON, BJ

HOOPER, ML

MURPHY, PR

ROBERTSON, HA

机构：

[1] DALHOUSIE UNIV, FAC MED, DEPT PHARMACOL, HALIFAX B3H 4H7, NS, CANADA

[2] DALHOUSIE UNIV, FAC MED, DEPT PHYSIOL & BIOPHYS, HALIFAX B3H 4H7, NS, CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 227卷 / 04期

关键词：

STRIATUM; PHOSPHOROTHIOATE; IMMEDIATE-EARLY GENES;

D O I：

10.1016/0922-4106(92)90167-T

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Immediate-early genes such as c-fos and NGFI-A are rapidly and transiently expressed in the striatum following amphetamine administration in vivo. Here we show that direct infusion of an antisense oligodeoxynucleotide to c-fos into striatum will reduce amphetamine-induced production of Fos-like immunoreactivity without affecting NGFI-A expression. These results suggest that it is possible to use antisense technology to study the role of immediate-early genes in specific sites in the brain in vivo.

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收藏

页码：451 / 453

页数：3

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