CYSTEAMINE INDUCED-DUODENAL ULCERS ARE ASSOCIATED WITH A SELECTIVE DEPLETION IN GASTRIC AND DUODENAL CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVITY IN RATS

被引:11
作者
EVANGELISTA, S
RENZI, D
TRAMONTANA, M
SURRENTI, C
THEODORSSON, E
MAGGI, CA
机构
[1] UNIV FLORENCE,DEPT CLIN PATHOPHYSIOL,GASTROENTEROL UNIT,I-50121 FLORENCE,ITALY
[2] KAROLINSKA INST,DEPT CLIN CHEM,S-10401 STOCKHOLM 60,SWEDEN
[3] MENARINI PHARMACEUT,DEPT PHARMACOL,FLORENCE,ITALY
关键词
CALCITONIN GENE-RELATED PEPTIDE (CGRP); PEPTIDE; GASTRIC LESION; DUODENAL ULCER; CAPSAICIN; CYSTEAMINE;
D O I
10.1016/0167-0115(92)90004-E
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We have measured the endogenous levels of gastric and duodenal calcitonin gene-related peptide (CGRP)-, neurokinin A (NKA)-, galanin-vasoactive intestinal polypeptide (VIP)- and neuropeptide Y (NPY)-like immunoreactivity (li) in relation to cysteamine-induced gastric lesions and duodenal ulcers in rats. CGRP-li but not NKA-, galanin-, VIP- or NPY-li was decreased in gastric and duodenal samples following a single ulcerogenic dose of cysteamine (900 mg/kg p.o.). Temporal relationships of this phenomenon showed that CGRP-li was selectively decreased (stomach 45%, duodenum 68% as compared to controls, respectively after 24 h) concomitantly to the formation of acute gastric lesions and duodenal ulcers. Animals bearing healed ulcers 12 days after cysteamine, had gastroduodenal CGRP-li similar to control values. Pretreatment with the selective sensory neurotoxin capsaicin decreased gastroduodenal CGRP-li but not NKA-, galanin-, VIP- or NPY-ti, showing that CGRP might be considered a marker of the afferent innervation of the gastroduodenal tract. The residual gastroduodenal CGRP-li levels in capsaicin-pretreated animals were not decreased by cysteamine administration, indicating that the effect of cysteamine is restricted to a peptide pool of primary afferent origin. Duodenal CGRP-li is selectively decreased by the duodenal ulcerogen cysteamine during the acute phase of ulcers formation and might be among the local mediators which afford protection against the ulcerogenic stimuli.
引用
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页码:19 / 28
页数:10
相关论文
共 26 条
[1]   NEONATAL CAPSAICIN DOES NOT AFFECT UNMYELINATED EFFERENT FIBERS OF THE AUTONOMIC NERVOUS-SYSTEM - FUNCTIONAL EVIDENCE [J].
CERVERO, F ;
MCRITCHIE, HA .
BRAIN RESEARCH, 1982, 239 (01) :283-288
[2]  
DIPETTE DJ, 1987, HYPERTENSION, V9, P142
[3]   THE BROWN,G.L. LECTURE - REGULATORY PEPTIDES AND THE NEUROENDOCRINOLOGY OF GUT BRAIN RELATIONS [J].
DOCKRAY, GJ .
QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 1988, 73 (05) :703-727
[4]   DUODENAL-ULCERS ARE ASSOCIATED WITH A DEPLETION OF DUODENAL CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVITY IN RATS [J].
EVANGELISTA, S ;
RENZI, D ;
MANTELLINI, P ;
SURRENTI, C ;
MELI, A .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 164 (02) :389-391
[5]  
EVANGELISTA S, 1988, INT J TISSUE REACT, V10, P253
[6]   DIFFERENTIAL EFFECT ON NEUROPEPTIDE RELEASE OF DIFFERENT CONCENTRATIONS OF HYDROGEN-IONS ON AFFERENT AND INTRINSIC NEURONS OF THE RAT STOMACH [J].
GEPPETTI, P ;
TRAMONTANA, M ;
EVANGELISTA, S ;
RENZI, D ;
MAGGI, CA ;
FUSCO, BM ;
DELBIANCO, E .
GASTROENTEROLOGY, 1991, 101 (06) :1505-1511
[7]  
GREEN T, 1988, NEUROSCIENCE, V25, P181
[8]   SENSORY NEURONS SIGNAL FOR AN INCREASE IN RAT GASTRIC-MUCOSAL BLOOD-FLOW IN THE FACE OF PENDING ACID INJURY [J].
HOLZER, P ;
LIVINGSTON, EH ;
GUTH, PH .
GASTROENTEROLOGY, 1991, 101 (02) :416-423
[9]   RELEASE OF CALCITONIN GENE-RELATED PEPTIDE INDUCED BY CAPSAICIN IN THE VASCULARLY PERFUSED RAT STOMACH [J].
HOLZER, P ;
PESKAR, BM ;
PESKAR, BA ;
AMANN, R .
NEUROSCIENCE LETTERS, 1990, 108 (1-2) :195-200
[10]   GASTRIC-MUCOSAL PROTECTION AGAINST ULCEROGENIC FACTORS IN THE RAT MEDIATED BY CAPSAICIN-SENSITIVE AFFERENT NEURONS [J].
HOLZER, P ;
SAMETZ, W .
GASTROENTEROLOGY, 1986, 91 (04) :975-981