BIOSYNTHESIS OF VITAMIN-B(12) - THE FATE OF 8-H AS PRECORRIN-2 IS ENZYMATICALLY CONVERTED INTO COBYRINIC ACID

被引：3

作者：

KODERA, M ^{[1
]}

LEEPER, FJ ^{[1
]}

BATTERSBY, AR ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,CHEM LAB,LENSFIELD RD,CAMBRIDGE CB2 1EW,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 11期

关键词：

D O I：

10.1039/c39920000835

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The dimethylated B-12-Precursor, precorrin-2 2, is prepared strongly labelled with tritium at 3-H and 8-H to allow proof that the 3-H label is retained where as the 8-H label is lost during the biosynthetic conversion of precorrin-2 into cobyrinic acid 3.

引用

页码：835 / 837

页数：3

共 23 条

[1]

ARIGONI D, UNPUB

[2] BIOSYNTHESIS OF VITAMIN-B12 - PROOF OF A-B STRUCTURE FOR SIROHYDROCHLORIN BY ITS SPECIFIC INCORPORATION INTO COBYRINIC ACID [J].

BATTERSBY, AR ;

MCDONALD, E ;

THOMPSON, M ;

BYKHOVSKY, VY .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1978, (03) :150-151

[3]

BATTERSBY AR, 1977, TETRAHEDRON LETT, P2213

[4]

BATTERSBY AR, 1982, J CHEM SOC PERK T 1, P2265, DOI 10.1039/p19820002265

[5] BIOSYNTHESIS OF PORPHYRINS AND RELATED MACROCYCLES .10. VITAMIN-B12 - BIOCHEMICAL DERIVATION OF COBYRINIC ACID FROM UROPORPHYRINOGEN-3, STUDIES WITH CORRESPONDING RING-C METHYL HEPTACARBOXYLIC PORPHYRINOGEN, AND PROOF OF 7 INTACT METHYL TRANSFERS [J].

BATTERSBY, AR ;

MCDONALD, E ;

HOLLENSTEIN, R ;

IHARA, M ;

SATOH, F ;

WILLIAMS, DC .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1977, (02) :166-178

[6]

BATTERSBY AR, 1977, TETRAHEDRON LETT, P2217

[7]

BATTERSBY AR, 1982, J CHEM SOC CHEM COMM, P455

[8]

BATTERSBY AR, 1987, J CHEM SOC P1, P1689

[9]

BLADON C, 1984, RES REPORT

[10] BIOSYNTHESIS OF VITAMIN-B12 - USE OF A SINGLE C-13 LABEL IN THE MACROCYCLE TO CONFIRM C-11 METHYLATION IN PRECORRIN-6X [J].

BLANCHE, F ;

KODERA, M ;

COUDER, M ;

LEEPER, FJ ;

THIBAUT, D ;

BATTERSBY, AR .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (02) :138-139

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