MASSIVE STRYCHNINE INTOXICATION - SERIAL BLOOD-LEVELS IN A FATAL CASE

被引：27

作者：

HEISER, JM

DAYA, MR

MAGNUSSEN, AR

NORTON, RL

SPYKER, DA

ALLEN, DW

KRASSELT, W

机构：

[1] OREGON HLTH SCI UNIV, PORTLAND, OR 97201 USA

[2] US FDA, ROCKVILLE, MD 20857 USA

[3] LA GRANDE CLIN, LA GRANDE, OR USA

来源：

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | 1992年 / 30卷 / 02期

关键词：

STRYCHNINE; POISONING; HUMAN; PHARMACOKINETICS; REVIEW;

D O I：

10.3109/15563659209038638

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A fatal case of strychnine intoxication is reported. The patient expired despite early aggressive management and prevention of metabolic complications. Serial blood levels are reported. In contrast to a previous report describing first order elimination kinetics, our data suggest that strychnine follows Michaelis-Menton elimination kinetics. The case illustrates the rapid, dramatic course of severe strychnine ingestions. A review of the toxicokinetics, mechanism of action and treatment of strychnine intoxication follows.

引用

页码：269 / 283

页数：15

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