DIRECT EXPERIMENTAL-EVIDENCE FOR COMPETITIVE-INHIBITION OF DIHYDROFOLATE-REDUCTASE BY METHOTREXATE

被引:12
作者
WALTHAM, MC
HOLLAND, JW
ROBINSON, SC
WINZOR, DJ
NIXON, PF
机构
[1] UNIV QUEENSLAND,DEPT BIOCHEM,ST LUCIA,QLD 4067,AUSTRALIA
[2] PRINCESS ALEXANDRA HOSP,WOOLOONGABBA,QLD 4102,AUSTRALIA
关键词
D O I
10.1016/0006-2952(88)90225-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:535 / 539
页数:5
相关论文
共 26 条
[1]  
BENKOVIC S J, 1986, P13
[2]   ROLE OF ISOMERIZATION OF INITIAL COMPLEXES IN THE BINDING OF INHIBITORS TO DIHYDROFOLATE-REDUCTASE [J].
BLAKLEY, RL ;
COCCO, L .
BIOCHEMISTRY, 1985, 24 (18) :4772-4777
[3]   CRYSTALLINE DIHYDROPTEROYLGLUTAMIC ACID [J].
BLAKLEY, RL .
NATURE, 1960, 188 (4746) :231-232
[4]  
BLAKLEY RL, 1985, BIOCHEMISTRY-US, V24, P4704, DOI 10.1021/bi00338a032
[5]  
BLAKLEY RL, 1971, ANN NY ACAD SCI, V196, P119
[6]   TIGHT-BINDING INHIBITORS .1. KINETIC-BEHAVIOR [J].
CHA, S .
BIOCHEMICAL PHARMACOLOGY, 1975, 24 (23) :2177-2185
[7]   TIGHT-BINDING INHIBITORS .2. NON-STEADY STATE NATURE OF INHIBITION OF MILK XANTHINE-OXIDASE BY ALLOPURINOL AND ALLOXANTHINE AND OF HUMAN ERYTHROCYTIC ADENOSINE DEAMINASE BY COFORMYCIN [J].
CHA, S ;
AGARWAL, RP ;
PARKS, RE .
BIOCHEMICAL PHARMACOLOGY, 1975, 24 (23) :2187-2197
[8]   TIGHT-BINDING INHIBITORS .3. NEW APPROACH FOR DETERMINATION OF COMPETITION BETWEEN TIGHT-BINDING INHIBITORS AND SUBSTRATES-INHIBITION OF ADENOSINE-DEAMINASE BY COFORMYCIN [J].
CHA, S .
BIOCHEMICAL PHARMACOLOGY, 1976, 25 (24) :2695-2702
[9]   LARGE-SCALE PURIFICATION AND CHARACTERIZATION OF DIHYDROFOLATE-REDUCTASE FROM A METHOTREXATE-RESISTANT STRAIN OF LACTOBACILLUS-CASEI [J].
DANN, JG ;
OSTLER, G ;
BJUR, RA ;
KING, RW ;
SCUDDER, P ;
TURNER, PC ;
ROBERTS, GCK ;
BURGEN, ASV ;
HARDING, NGL .
BIOCHEMICAL JOURNAL, 1976, 157 (03) :559-571
[10]  
Dawson R.M.C., 1969, DATA BIOCH RES