ROLE OF ISOMERIZATION OF INITIAL COMPLEXES IN THE BINDING OF INHIBITORS TO DIHYDROFOLATE-REDUCTASE

被引：22

作者：

BLAKLEY, RL

COCCO, L

机构：

来源：

BIOCHEMISTRY | 1985年 / 24卷 / 18期

关键词：

D O I：

10.1021/bi00339a010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：4772 / 4777

页数：6

共 12 条

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[2]

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[3]

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[5] PROTONATED STATE OF METHOTREXATE, TRIMETHOPRIM, AND PYRIMETHAMINE BOUND TO DIHYDROFOLATE-REDUCTASE [J].

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[6] KINETICS OF LIGAND-BINDING TO DIHYDROFOLATE-REDUCTASE - BINARY COMPLEX-FORMATION WITH NADPH AND COENZYME ANALOGS [J].

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[7] KINETICS OF TERNARY COMPLEX-FORMATION BETWEEN DIHYDROFOLATE-REDUCTASE, COENZYME, AND INHIBITORS [J].

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[8]

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[9]

MATTHEWS DA, 1985, J BIOL CHEM, V260, P381

[10] INHIBITION OF DIHYDROFOLATE-REDUCTASE FROM BACTERIAL AND VERTEBRATE SOURCES BY FOLATE, AMINOPTERIN, METHOTREXATE AND THEIR 5-DEAZA ANALOGS [J].

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BIOCHEMICAL PHARMACOLOGY, 1984, 33 (02) :175-179

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