A DROSOPHILA GENE THAT IS HOMOLOGOUS TO A MAMMALIAN GENE ASSOCIATED WITH TUMOR-METASTASIS CODES FOR A NUCLEOSIDE DIPHOSPHATE KINASE

被引：361

作者：

BIGGS, J ^{[1
]}

HERSPERGER, E ^{[1
]}

STEEG, PS ^{[1
]}

LIOTTA, LA ^{[1
]}

SHEARN, A ^{[1
]}

机构：

[1] NCI,PATHOL LAB,BETHESDA,MD 20892

来源：

CELL | 1990年 / 63卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0092-8674(90)90496-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The product of the abnormal wing discs (awd) gene of Drosophila is 78% identical to the product of the nm23 gene of mammais, which is differentially expressed in certain metastatic tumors. We present evidence that the awd gene codes for a nucleoside diphosphate kinase (NDP kinase) and that this Awd/NDP kinase is microtubule associated. Neuroblasts in Drosophila larvae homozygous for a null mutation in the awd gene are arrested in metaphase, indicating that microtubule-associated Awd/NDP kinase plays a critical role in spindle microtubule polymerization. © 1990.

引用

页码：933 / 940

页数：8

共 33 条

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