SUBDIAPHRAGMATIC VAGOTOMY DOES NOT INFLUENCE THE ANORECTIC EFFECT OF AMYLIN

被引：73

作者：

LUTZ, TA

DELPRETE, E

SCHARRER, E

机构：

[1] Institute of Veterinary Physiology, University of Zuerich, 8057 Zuerich

来源：

PEPTIDES | 1995年 / 16卷 / 03期

关键词：

AMYLIN; IP INJECTION; FOOD INTAKE; SUBDIAPHRAGMATIC VAGOTOMY; GASTRIC EMPTYING; RAT;

D O I：

10.1016/0196-9781(94)00203-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amylin injected IP reduced food intake for 2-4 h in subdiaphragmatically vagotomized and in sham-vagotomized rats. The magnitude of the anorectic effect of 0.5 mu g/kg amylin was similar to that of 2.5 mu g/kg amylin but the duration of the effect was somewhat shorter with the low dose. Amylin (1 mu g/kg, IF) had no influence on gastric emptying. In conclusion, the hypophagic effect of peripherally administered amylin does not depend on an intact abdominal vagus or on an indirect effect via gastric emptying. It may therefore be hypothesized that amylin has a central site of action.

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页码：457 / 462

页数：6

相关论文

共 40 条

[1] SYNTHESES, STRUCTURES AND ANORECTIC EFFECTS OF HUMAN AND RAT AMYLIN [J].

BALASUBRAMANIAM, A ;

RENUGOPALAKRISHNAN, V ;

STEIN, M ;

FISCHER, JE ;

CHANCE, WT .

PEPTIDES, 1991, 12 (05) :919-924

[2] PEPTIDE-TRANSPORT SYSTEMS FOR OPIATES ACROSS THE BLOOD-BRAIN-BARRIER [J].

BANKS, WA ;

KASTIN, AJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (01) :E1-E10

[3] SATURABLE TRANSPORT OF INSULIN FROM PLASMA INTO THE CENTRAL-NERVOUS-SYSTEM OF DOGS IN-VIVO - A MECHANISM FOR REGULATED INSULIN DELIVERY TO THE BRAIN [J].

BAURA, GD ;

FOSTER, DM ;

PORTE, D ;

KAHN, SE ;

BERGMAN, RN ;

COBELLI, C ;

SCHWARTZ, MW .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (04) :1824-1830

[4]

BAYBOULD HE, 1992, NEUROANATOMY PHYSL A, P194

[5]

BEAUMONT K, 1993, MOL PHARMACOL, V44, P493

[6] STRUCTURE OF CAT ISLET AMYLOID POLYPEPTIDE AND IDENTIFICATION OF AMINO-ACID-RESIDUES OF POTENTIAL SIGNIFICANCE FOR ISLET AMYLOID FORMATION [J].

BETSHOLTZ, C ;

CHRISTMANSON, L ;

ENGSTROM, U ;

RORSMAN, F ;

JORDAN, K ;

OBRIEN, TD ;

MURTAUGH, M ;

JOHNSON, KH ;

WESTERMARK, P .

DIABETES, 1990, 39 (01) :118-122

[7] INVESTIGATION AND CHARACTERIZATION OF BINDING-SITES FOR ISLET AMYLOID POLYPEPTIDE IN RAT MEMBRANES [J].

BHOGAL, R ;

SMITH, DM ;

BLOOM, SR .

ENDOCRINOLOGY, 1992, 130 (02) :906-913

[8] EFFECTS OF MEAL INGESTION ON PLASMA AMYLIN CONCENTRATION IN NIDDM AND NONDIABETIC HUMANS [J].

BUTLER, PC ;

CHOU, J ;

CARTER, WB ;

WANG, YN ;

BU, BH ;

CHANG, D ;

CHANG, JK ;

RIZZA, RA .

DIABETES, 1990, 39 (06) :752-756

[9] TESTS OF ADIPSIA AND CONDITIONED TASTE-AVERSION FOLLOWING THE INTRAHYPOTHALAMIC INJECTION OF AMYLIN [J].

CHANCE, WT ;

BALASUBRAMANIAM, A ;

CHEN, X ;

FISCHER, JE .

PEPTIDES, 1992, 13 (05) :961-964

[10] ANOREXIA FOLLOWING THE SYSTEMIC INJECTION OF AMYLIN [J].

CHANCE, WT ;

BALASUBRAMANIAM, A ;

STALLION, A ;

FISCHER, JE .

BRAIN RESEARCH, 1993, 607 (1-2) :185-188

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