New insights into insulin: The anti-inflammatory effect and its clinical relevance

被引：205

作者：

Qiang Sun ^{[1
]}

Jia Li ^{[1
]}

Feng Gao ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Sch Basic Med Sci, Dept Physiol, 169 Changlexi Rd, Xian 710032, Shannxi Prov, Peoples R China

来源：

WORLD JOURNAL OF DIABETES | 2014年 / 5卷 / 02期

基金：

中国国家自然科学基金; 国家自然科学基金重点项目;

关键词：

Insulin; Inflammation; Hyperglycemia;

D O I：

10.4239/wjd.v5.i2.89

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Hyperglycemia, a commonly exhibited metabolic disorder in critically ill patients, activates the body's inflammatory defense mechanism, causing the waterfall release of numerous inflammatory mediators and cytokines, and eventually leads to organ damage. As the only glucose-lowering hormone in the body, insulin not only alleviates the detrimental effects of hyperglycemia through its metabolic regulation, but also directly modulates inflammatory mediators and acts upon immune cells to enhance immunocompetence. In this sense, hyperglycemia is pro-inflammatory whereas insulin is anti-inflammatory. Therefore, during the past 50 years, insulin has not only been used in the treatment of diabetes, but has also been put into practical use in dealing with cardiovascular diseases and critical illnesses. This review summarizes the recent advances regarding the anti-inflammatory effects of insulin in both basic research and clinical trials, with the hope of aiding in the design of further experimental research and promoting effective insulin administration in clinical practice. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.

引用

页码：89 / 96

页数：8

共 68 条

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[2]

Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations [J].