INCREASED LEVELS OF SEQUENCE-SPECIFIC DNA-BINDING PROTEINS IN HUMAN CYTOMEGALOVIRUS-INFECTED CELLS

被引：28

作者：

BOLDOGH, I

FONS, MP

ALBRECHT, T

机构：

[1] Department of Microbiology, University of Texas Medical Branch, Galveston

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.2647

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Increased levels of active sequence-specific DNA-binding proteins, AP-1, CRE/B, and NFκB were observed in nuclear lysates of human cytomegalovirus-infected cells from 15 min postinfection. The activation of these cellular factors did not require infectious virus or de novo viral protein synthesis, but their abundance was significantly reduced by inhibitors of protein kinase C and/or A. These data suggest that formation of these transcription factors resulted from the virus-cell membrane interaction and/or through the action of virion structural proteins on cytoplasmic forms of these cellular factors. © 1993 Academic Press, Inc.

引用

收藏

页码：1505 / 1510

页数：6

相关论文

共 25 条

[11] ACTIVATION INVITRO OF NF-KAPPA-B BY PHOSPHORYLATION OF ITS INHIBITOR I-KAPPA-B [J].

GHOSH, S ;

BALTIMORE, D .

NATURE, 1990, 344 (6267) :678-682

[12] CELLS INFECTED WITH HUMAN CYTOMEGALOVIRUS RELEASE A FACTOR(S) THAT STIMULATES CELL-DNA SYNTHESIS [J].

GONCZOL, E ;

PLOTKIN, SA .

JOURNAL OF GENERAL VIROLOGY, 1984, 65 (OCT) :1833-1837

[13] CHARACTERIZATION OF A CAMP-REGULATED ENHANCER-BINDING PROTEIN [J].

HABENER, JF ;

MEYER, TE ;

YUN, YD ;

WAEBER, G ;

HOEFFLER, JP .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1990, 39 (09) :13-16

[14] ISOQUINOLINESULFONAMIDES, NOVEL AND POTENT INHIBITORS OF CYCLIC-NUCLEOTIDE DEPENDENT PROTEIN-KINASE AND PROTEIN KINASE-C [J].

HIDAKA, H ;

INAGAKI, M ;

KAWAMOTO, S ;

SASAKI, Y .

BIOCHEMISTRY, 1984, 23 (21) :5036-5041

[15] IMMEDIATE EARLY ANTIGENS IN HUMAN CYTOMEGALOVIRUS INFECTED-CELLS [J].

HORODNICEANU, F ;

GUILLON, JC .

NATURE, 1977, 270 (5638) :615-617

[16] TRANSCRIPTION FACTOR AP-2 MEDIATES INDUCTION BY 2 DIFFERENT SIGNAL-TRANSDUCTION PATHWAYS - PROTEIN-KINASE-C AND CAMP [J].

IMAGAWA, M ;

CHIU, R ;

KARIN, M .

CELL, 1987, 51 (02) :251-260

[17] MULTIPLE MECHANISMS ARE IMPLICATED IN THE REGULATION OF NF-KAPPA-B ACTIVITY DURING HUMAN CYTOMEGALOVIRUS-INFECTION [J].

KOWALIK, TF ;

WING, B ;

HASKILL, JS ;

AZIZKHAN, JC ;

BALDWIN, AS ;

HUANG, ES .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (03) :1107-1111

[18]

LANDINI MP, 1988, PROG MED VIROL, V35, P152

[19] HUMAN CYTOMEGALOVIRUS CONTAINS A TEGUMENT PROTEIN THAT ENHANCES TRANSCRIPTION FROM PROMOTERS WITH UPSTREAM ATF AND AP-1 CIS-ACTING ELEMENTS [J].

LIU, B ;

STINSKI, MF .

JOURNAL OF VIROLOGY, 1992, 66 (07) :4434-4444

[20]

MARZLUFF WF, 1990, METHOD ENZYMOL, V181, P30