Preparative scale enantioseparation of 1-cyclohexyl-1-phenylethyl hydroperoxide and 1,2,3,4-tetrahydro-1-naphthyl hydroperoxide on a modified cellulose stationary phase

被引：6

作者：

Wagner, J ^{[1
]}

Hamann, HJ ^{[1
]}

Dopke, W ^{[1
]}

Kunath, A ^{[1
]}

Hoft, E ^{[1
]}

机构：

[1] INST APPL CHEM ADLERSHOF,BERLIN,GERMANY

来源：

CHIRALITY | 1995年 / 7卷 / 04期

关键词：

chiral HPLC; cellulose tris(3,5-dimethylphenyl carbamate); hydroperoxides; enantiomers; circular dichroism;

D O I：

10.1002/chir.530070410

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The analytical and preparative scale optical resolution of 1-cyclohexyl-1-phenylethyl hydroperoxide and 1,2,3,4-tetrahydro-1-naphthyl hydroperoxide has been achieved by chiral HPLC on a cellulose tris(3,5-dimethylphenyl carbamate) stationary phase coated on silica gel. The method has been used to obtain several hundred milligrams of highly enriched enantiomers (%ee >98) which were characterized by [alpha](D) and circular dichroism spectra, respectively. Configurational assignments were achieved for 1,2,3,4-tetrahydro-1-naphthyl hydroperoxide enantiomers. (C) 1995 Wiley-Liss, Inc.

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页码：243 / 247

页数：5

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