DEVELOPMENT OF LUNG-FUNCTION IN RELATION TO INCREASED DEGREE OF BRONCHIAL RESPONSIVENESS

被引：7

作者：

BACKER, V ^{[1
]}

ULRIK, CS ^{[1
]}

机构：

[1] UNIV COPENHAGEN HOSP,RIGSHOSP,DEPT MED B,RESP PHYSIOL LAB,DK-2100 COPENHAGEN,DENMARK

来源：

JOURNAL OF ASTHMA | 1992年 / 29卷 / 05期

关键词：

D O I：

10.3109/02770909209044793

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

To study the relationship between development of lung function and bronchial responsiveness, we examined 106 subjects recruited from a random sample of 527 subjects, aged 8-18 years, from Copenhagen. Lung function and bronchial responsiveness to inhaled histamine were measured at two occasions, in 1986 and 1988. The participating subjects (n = 106) were divided into three groups: (a) 20 asthmatics with bronchial hyperresponsiveness (BHR), (b) 42 nonasthmatic subjects with BHR in 1986, and (c) 44 controls without BHR. In 1986, FEV1 expressed as percentage of predicted value, was found to be similar in the three groups (91 %, 94%, and 99%, respectively). The increase in height during the observation period was found to be 5, 6, and 6 cm, respectively, in the three groups. However, at the second examination, in 1988, FEV1 was found to be significantly reduced in both asthmatics (87%) and nonasthmatic subjects (85%) compared with the controls (103%). In 1988, 16 asthmatics (80%) and 24 (57%) nonasthmatic subjects were found to have BHR, whereas none of the controls were found to have BHR. A multiple regression analysis was used to determine the correlation between change in FEV1 and potential factors of importance. The change in FEV1 was highly correlated with the presence of BHR in 1986, however, no correlation was found between change in FEV, and change in bronchial responsiveness. In conclusion, nonasthmatic subjects with former BHR showed signs of airflow obstruction and less increase in lung function during growth irrespective of the change in level of bronchial responsiveness, which may suggest a risk for subsequent development of obstructive lung disease.

引用

页码：331 / 341

页数：11

共 27 条

[21] Fowler R.W., Pluck R.A., Hetzel M.R., Maximal expiratory flow-volume curves in Londoners aged 60 years and over, Thorax, 42, (1987)
[22] Barbato A., Pisetta F., Ragusa A., Marcer G., Zacchello F., Modification of bronchial hyperreactivity during pollen season in children allergic to grass, Ann Allergy, 58, (1987)
[23] Boulet L.-P., Cartier A., Thomson N.C., Roberts R.S., Tech M., Dolovich J., Hargreave F.E., Asthma and increases in nonallergic bronchial responsiveness from seasonal pollen exposure, J Allergy Clin Immunol, 71, (1983)
[24] Martin A.J., Landau L.I., Phelan P.D., Lung function in young adults who had asthma in childhood, Am Rev Respir Dis, 122, (1980)
[25] Grainger D.N., Stenton S.C., Avery A.J., Duddridge M., Walters E.H., Hendrick D.J., The relationship between atopy and non-specific bronchial responsiveness, Clin Exp Allergy, 20, (1990)
[26] Van Asperen P.P., Kemp A.S., Mukhi A., Atopy in infancy predicts the severity of bronchial hyperresponsiveness in later childhood, J Allergy Clin Immunol, 85, (1990)
[27] Hopp R.J., Bewtra A., Nair N.M., Townley R.G., The effect of age on methacholine response, J Allergy Clin Immunol, 76, (1985)

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