CUTANEOUS ULTRAVIOLET-RADIATION INHIBITS HERPES-SIMPLEX VIRUS-INDUCED LYMPHOPROLIFERATION IN LATENTLY INFECTED SUBJECTS

被引：16

作者：

MIURA, S

KULKA, TM

SMITH, CC

IMAFUKU, S

BURNETT, JW

AURELIAN, L

机构：

[1] UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,VIROL IMMUNOL LABS,BALTIMORE,MD 21201

[2] UNIV MARYLAND,SCH MED,DEPT DERMATOL,BALTIMORE,MD 21201

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1994年 / 72卷 / 01期

关键词：

D O I：

10.1006/clin.1994.1107

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Exposure of herpes simplex virus (HSV) latently infected subjects to ultraviolet irradiation (UVR) (1 minimum erythema dose, 90% body surface) caused a significant inhibition of HSV and phytohemagglutinin-induced lymphoproliferation. The inhibition was observed on Day 3 post-UVR and lasted at least 9 days. UVR-induced downregulation of HSV-specific lymphoproliferation was associated with increased levels of activated transforming growth factor beta. However, the relationship between UVR-induced immune downregulation and the development of recurrent HSV lesions was incomplete. (C) 1994 Academic Press, Inc.

引用

页码：62 / 69

页数：8

共 42 条

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