CHROMOGRANIN-A IN HUMAN HYPERTENSION - INFLUENCE OF HEREDITY

被引：99

作者：

TAKIYYUDDIN, MA

PARMER, RJ

KAILASAM, MT

CERVENKA, JH

KENNEDY, B

ZIEGLER, MG

LIN, MC

LI, J

GRIM, CE

WRIGHT, FA

OCONNOR, DT

机构：

[1] UNIV CALIF SAN DIEGO,DEPT MED,DIV NEPHROL HYPERTENS 9111H,SAN DIEGO,CA 92161

[2] UNIV CALIF SAN DIEGO,DEPT FAMILY & PREVENT MED,SAN DIEGO,CA 92161

[3] DEPT VET AFFAIRS MED CTR,SAN DIEGO,CA

[4] CHARLES R DREW UNIV MED & SCI,LOS ANGELES,CA 90059

来源：

HYPERTENSION | 1995年 / 26卷 / 01期

关键词：

CHROMOGRANINS; HYPERTENSION; ESSENTIAL; ADRENAL MEDULLA; GENETICS;

D O I：

10.1161/01.HYP.26.1.213

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Multiple heritable traits are associated with essential (genetic) hypertension in humans. Because chromogranin A is increased in both human and rodent genetic hypertension, we examined the influence of heredity and blood pressure on chromogranin A in humans. In estimates derived from among- and within-pair variance in monozygotic versus dizygotic twins, plasma chromogranin A displayed significant (F-15,F-18=2.93, P=.016) genetic variance (sigma(g)(2)), and its broad-sense heritability was high (h(B)(2)=0.983). Plasma chromogranin A was increased in essential hypertension (99.9+/-6.7 versus 62.8+/-4.7 ng/mL, P<.001) but was influenced little by genetic risk for (family history of) hypertension (in normotensive or hypertensive subjects), by race, or by several antihypertensive therapies (angiotensin-converting enzyme inhibitor, diuretic, or beta-adrenergic antagonist). In normotensive subjects at genetic risk for essential hypertension, neither basal nor sympathoadrenal stress-evoked chromogranin A differed from values found in subjects not at risk. In established essential hypertension, plasma chromogranin A responses to adrenal medullary (insulin-evoked hypoglycemia) or sympathetic neuronal (dynamic exercise) activation were exaggerated, whereas responses to sympathoadrenal suppression (ganglionic blockade) were diminished, suggesting increased vesicular stores of chromogranin A and an adrenergic origin of the augmented chromogranin A expression in this disorder. We conclude that plasma chromogranin A displays substantial heritability and is increased in established essential hypertension. Its elevation in established hypertension is associated with evidence of increased vesicular stores of the protein and with adrenergic hyperactivity but is influenced little by customary antihypertensive therapies. However, the chromogranin A elevation is not evident early in the course of genetic hypertension.

引用

页码：213 / 220

页数：8

共 53 条

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