CROSS-REACTIVE ANTIGENS BETWEEN LIFE-CYCLE STAGES OF PLASMODIUM-FALCIPARUM

被引：14

作者：

MOELANS, IIMD

SCHOENMAKERS, JGG

机构：

[1] Department of Molecular Biology, University of Nijmegen

来源：

PARASITOLOGY TODAY | 1992年 / 8卷 / 04期

关键词：

D O I：

10.1016/0169-4758(92)90278-A

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The high mortality and morbidity induced by falciparum malaria has motivated research to find an efficient antimalarial vaccine. The parasite has a complex life cycle, both in the mosquito and human hosts, and presents a number of potential targets for vaccine-induced immune attack. Here, Inge Moelans and John Schoenmakers discuss how the search for protective antigens has been complicated by the discovery of multiple crossreactivities between different parasite proteins.

引用

收藏

页码：118 / 123

页数：6

相关论文

共 40 条

[21] REPETITIVE PROTEINS AND GENES OF MALARIA [J].

KEMP, DJ ;

COPPEL, RL ;

ANDERS, RF .

ANNUAL REVIEW OF MICROBIOLOGY, 1987, 41 :181-208

[22] STRUCTURE AND POSSIBLE FUNCTION OF PLASMODIUM-FALCIPARUM PROTEINS EXPORTED TO THE ERYTHROCYTE-MEMBRANE [J].

KNAPP, B ;

HUNDT, E ;

LINGELBACH, KR .

PARASITOLOGY RESEARCH, 1991, 77 (04) :277-282

[23] CYTO-TOXIC T-CELLS SPECIFIC FOR THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM [J].

KUMAR, S ;

MILLER, LH ;

QUAKYI, IA ;

KEISTER, DB ;

HOUGHTEN, RA ;

MALOY, WL ;

MOSS, B ;

BERZOFSKY, JA ;

GOOD, MF .

NATURE, 1988, 334 (6179) :258-260

[24] MONOCLONAL ANTI-GAMETOCYTE ANTIBODIES IDENTIFY AN ANTIGEN PRESENT IN ALL BLOOD STAGES OF PLASMODIUM-FALCIPARUM [J].

MASUDA, A ;

ZAVALA, F ;

NUSSENZWEIG, V ;

NUSSENZWEIG, RS .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1986, 19 (03) :213-222

[25] CROSS-REACTIVE ANTIGENIC DETERMINANTS PRESENT ON DIFFERENT PLASMODIUM-FALCIPARUM BLOOD-STAGE ANTIGENS [J].

MATTEI, D ;

BERZINS, K ;

WAHLGREN, M ;

UDOMSANGPETCH, R ;

PERLMANN, P ;

GRIESSER, HW ;

SCHERF, A ;

MULLERHILL, B ;

BONNEFOY, S ;

GUILLOTTE, M ;

LANGSLEY, G ;

DASILVA, LP ;

MERCEREAUPUIJALON, O .

PARASITE IMMUNOLOGY, 1989, 11 (01) :15-29

[26] A NOVEL PROTEIN ANTIGEN OF THE MALARIA PARASITE PLASMODIUM-FALCIPARUM, LOCATED ON THE SURFACE OF GAMETES AND SPOROZOITES [J].

MOELANS, IIMD ;

MEIS, JFGM ;

KOCKEN, C ;

KONINGS, RNH ;

SCHOENMAKERS, JGG .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1991, 45 (02) :193-204

[27] MINIMAL VARIATION IN PFS16, A NOVEL PROTEIN LOCATED IN THE MEMBRANE OF GAMETES AND SPOROZOITES OF PLASMODIUM-FALCIPARUM [J].

MOELANS, IIMD ;

KLAASSEN, CHW ;

KASLOW, DC ;

KONINGS, RNH ;

SCHOENMAKERS, JGG .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1991, 46 (02) :311-313

[28]

PERLMANN P, 1986, VACCINES 86, P149

[29] THE GENE-PRODUCT OF THE PLASMODIUM-FALCIPARUM 11.1 LOCUS IS A PROTEIN LARGER THAN ONE MEGADALTON [J].

PETERSEN, C ;

NELSON, R ;

LEECH, J ;

JENSEN, J ;

WOLLISH, W ;

SCHERF, A .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1990, 42 (02) :189-195

[30] A LONGITUDINAL-STUDY OF ANTIBODIES TO THE PLASMODIUM-FALCIPARUM ANTIGEN PF155 RESA AND IMMUNITY TO MALARIA INFECTION IN ADULT LIBERIANS [J].

PETERSEN, E ;

HOGH, B ;

MARBIAH, NT ;

PERLMANN, H ;

WILLCOX, M ;

DOLOPAIE, E ;

HANSON, AP ;

BJORKMAN, A ;

PERLMANN, P .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1990, 84 (03) :339-345

← 1 2 3 4 →