DIFFERENTIAL-EFFECTS OF TUMOR-NECROSIS-FACTOR ON THE GROWTH AND DIFFERENTIATION OF NEUROBLASTOMA AND GLIOMA-CELLS

被引：28

作者：

MUNOZFERNANDEZ, MA ^{[1
]}

ARMASPORTELA, R ^{[1
]}

DIAZNIDO, J ^{[1
]}

ALONSO, JL ^{[1
]}

FRESNO, M ^{[1
]}

AVILA, J ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID,CSIC,CTR BIOL MOLEC,E-28049 MADRID,SPAIN

来源：

EXPERIMENTAL CELL RESEARCH | 1991年 / 194卷 / 01期

关键词：

D O I：

10.1016/0014-4827(91)90147-M

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have studied the effect of tumor necrosis factor (TNF-α) on transformed neural and glial-derived cell lines. TNF-α at physiological doses was able to arrest the growth and inhibit DNA synthesis of N103 neuroblastoma cells. This phenomenon was accompanied by a morphological cell differentiation characterized by the outgrowth of neurites. By contrast, TNF-α induced an increase in the growth rate of C6 glioma cells and upon cytokine addition a higher number of C6 cells were found in the S + G2 phase of the cell cycle. C6 cells did not show morphological changes under this treatment. Analogous results were obtained with IFN-γ. These neurotrophic and mitogenic effects of TNF-α suggest a putative role of this cytokine in the regeneration of brain tissue upon brain injury. © 1991.

引用

页码：161 / 164

页数：4

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