A REMOTE SYSTEM FOR THE SYNTHESIS OF COPPER-62 LABELED CU(PTSM)

被引：14

作者：

MATHIAS, CJ ^{[1
]}

MARGENAU, WH ^{[1
]}

BRODACK, JW ^{[1
]}

WELCH, MJ ^{[1
]}

GREEN, MA ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM,DEPT MED CHEM,DIV NUCL PHARM,W LAFAYETTE,IN 47907

来源：

APPLIED RADIATION AND ISOTOPES | 1991年 / 42卷 / 03期

关键词：

D O I：

10.1016/0883-2889(91)90097-K

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The construction and performance of a remote system is described for the synthesis of Cu-62-labeled pyruvaldehyde bis(N4-methylthiosemicarbazonato)copper(II), [Cu-62]Cu-(PTSM), a positron-emitting radiopharmaceutical for perfusion imaging. The remote system allows the shielded synthesis and purification of tracer using the 2 M HCl eluate of high-level (10-18 GBq)Zn-62/Cu-62 radionuclide generator system. The remote system allows the [Cu-62]Cu(PTSM) synthesis to be performed in under 8 min with ca 40% E.O.S. radiochemical yield and > 98% radiochemical purity.

引用

页码：317 / 320

页数：4

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