A REMOTE SYSTEM FOR THE SYNTHESIS OF COPPER-62 LABELED CU(PTSM)

被引:14
作者
MATHIAS, CJ [1 ]
MARGENAU, WH [1 ]
BRODACK, JW [1 ]
WELCH, MJ [1 ]
GREEN, MA [1 ]
机构
[1] PURDUE UNIV,SCH PHARM,DEPT MED CHEM,DIV NUCL PHARM,W LAFAYETTE,IN 47907
关键词
D O I
10.1016/0883-2889(91)90097-K
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The construction and performance of a remote system is described for the synthesis of Cu-62-labeled pyruvaldehyde bis(N4-methylthiosemicarbazonato)copper(II), [Cu-62]Cu-(PTSM), a positron-emitting radiopharmaceutical for perfusion imaging. The remote system allows the shielded synthesis and purification of tracer using the 2 M HCl eluate of high-level (10-18 GBq)Zn-62/Cu-62 radionuclide generator system. The remote system allows the [Cu-62]Cu(PTSM) synthesis to be performed in under 8 min with ca 40% E.O.S. radiochemical yield and > 98% radiochemical purity.
引用
收藏
页码:317 / 320
页数:4
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