COOPERATIVE MOLECULAR MOTORS

被引:289
作者
JULICHER, F
PROST, J
机构
[1] SIMON FRASER UNIV,DEPT PHYS,BURNABY,BC V5A 1S6,CANADA
[2] ECOLE SUPER PHYS & CHIM IND VILLE PARIS,F-75231 PARIS 05,FRANCE
[3] INST CURIE,F-75231 PARIS 05,FRANCE
关键词
D O I
10.1103/PhysRevLett.75.2618
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
We present a simple stochastical model for motor molecules that cooperate in large groups. This model could apply for actin-myosin motors in muscles and for motility assays with a high concentration of motor molecules. We calculate the dependence of the velocity on the applied force as a function of ATP concentration and show the existence of a dynamical phase transition allowing for spontaneous directed motion even if the system is spatially symmetric. In the symmetric case, the problem is isomorphous to a paramagnet-ferromagnet transition, in the asymmetric case to a liquid-vapor transition.
引用
收藏
页码:2618 / 2621
页数:4
相关论文
共 20 条
[1]  
AJDARI A, 1992, CR ACAD SCI II, V315, P1635
[2]  
AJDARI A, 1992, THESIS U PARIS
[3]  
Alberts B, 1994, MOL BIOL CELL
[4]   FLUCTUATION DRIVEN RATCHETS - MOLECULAR MOTORS [J].
ASTUMIAN, RD ;
BIER, M .
PHYSICAL REVIEW LETTERS, 1994, 72 (11) :1766-1769
[5]   FORCE-FREE MOTION IN ASYMMETRIC STRUCTURES - A MECHANISM WITHOUT DIFFUSIVE STEPS [J].
CHAUWIN, JF ;
AJDARI, A ;
PROST, J .
EUROPHYSICS LETTERS, 1994, 27 (06) :421-426
[6]   GLIDING ASSAYS FOR MOTOR PROTEINS - A THEORETICAL-ANALYSIS [J].
DUKE, T ;
HOLY, TE ;
LEIBLER, S .
PHYSICAL REVIEW LETTERS, 1995, 74 (02) :330-333
[7]  
HUXLEY HE, 1969, SCIENCE, V164, P1365
[8]   SUB-PICONEWTON FORCE FLUCTUATIONS OF ACTOMYOSIN INVITRO [J].
ISHIJIMA, A ;
DOI, T ;
SAKURADA, K ;
YANAGIDA, T .
NATURE, 1991, 352 (6333) :301-306
[9]  
JULICHER F, IN PRESS RELAXING BA
[10]   PORTERS VERSUS ROWERS - A UNIFIED STOCHASTIC-MODEL OF MOTOR PROTEINS [J].
LEIBLER, S ;
HUSE, DA .
JOURNAL OF CELL BIOLOGY, 1993, 121 (06) :1357-1368