DEOXYRIBONUCLEOSIDE TRIPHOSPHATE LEVELS - A CRITICAL FACTOR IN THE MAINTENANCE OF GENETIC STABILITY

被引：191

作者：

KUNZ, BA

KOHALMI, SE

KUNKEL, TA

MATHEWS, CK

MCINTOSH, EM

REIDY, JA

机构：

[1] NATL RES COUNCIL CANADA, INST PLANT BIOTECHNOL, SASKATOON S7N 0W9, SK, CANADA

[2] NIEHS, MOLEC GENET LAB, RES TRIANGLE PK, NC 27709 USA

[3] OREGON STATE UNIV, DEPT BIOCHEM & BIOPHYS, CORVALLIS, OR 97331 USA

[4] YORK UNIV, DEPT BIOL, N YORK M3J 1P3, ON, CANADA

[5] CTR DIS CONTROL & PREVENT, NATL CTR ENVIRONM HLTH, MOLEC BIOL BRANCH, ATLANTA, GA 30341 USA

来源：

MUTATION RESEARCH-REVIEWS IN GENETIC TOXICOLOGY | 1994年 / 318卷 / 01期

关键词：

DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; GENETIC STABILITY;

D O I：

10.1016/0165-1110(94)90006-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA precursor pool imbalances can elicit a variety of genetic effects and modulate the genotoxicity of certain DNA-damaging agents. These and other observations indicate that the control of DNA precursor concentrations is essential for the maintenance of genetic stability, and suggest that factors which offset this control may contribute to environmental mutagenesis and carcinogenesis. In this article, we review the biochemical and genetic mechanisms responsible for regulating the production and relative amounts of intracellular DNA precursors, describe the many outcomes of perturbations in DNA precursor levels, and discuss implications of such imbalances for sensitivity to DNA-damaging agents, population monitoring, and human diseases.

引用

页码：1 / 64

页数：64

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