THE DISTINCTIVE SPECIFICITY OF ANTIGEN-SPECIFIC SUPPRESSOR T-CELLS

被引：94

作者：

SERCARZ, E ^{[1
]}

KRZYCH, U ^{[1
]}

机构：

[1] WALTER REED ARMY MED CTR, DEPT IMMUNOL, WASHINGTON, DC 20307 USA

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 04期

关键词：

D O I：

10.1016/0167-5699(91)90094-A

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although suppressor T cells have been cloned in only a few instances, the existence of a functional cadre of T cells that acts to downregulate the immune response is well documented. In this review Eli Sercarz and Urszula Krzych describe studies on suppressor T-cell (T(S)-cell) specificity that provide some support for the conclusion that the T(S) cell is a distinctive cell type with an expressed repertoire that is different from that expressed by helper T (T(H)) cells. They go on to explore the interaction between cells recognizing T(S)-cell-inducing determinants (SDs) and T(H)-cell-inducing determinants (HDs), and their relationship to immunogenicity and Ir gene effects.

引用

页码：111 / 118

页数：8

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