GENETIC-MAPPING OF A LOCUS PREDISPOSING TO HUMAN COLORECTAL-CANCER

被引：782

作者：

PELTOMAKI, P

AALTONEN, LA

SISTONEN, P

PYLKKANEN, L

MECKLIN, JP

JARVINEN, H

GREEN, JS

JASS, JR

WEBER, JL

LEACH, FS

PETERSEN, GM

HAMILTON, SR

DELACHAPELLE, A

VOGELSTEIN, B

机构：

[1] UNIV HELSINKI,DEPT MED GENET,POB 21,SF-00014 HELSINKI,FINLAND

[2] UNIV HELSINKI,DEPT MED SCI,SF-00310 HELSINKI,FINLAND

[3] FINNISH RED CROSS & BLOOD TRANSFUS SERV,BLOOD TRANSFUS SERV,SF-00310 HELSINKI,FINLAND

[4] JYVASKYLA CENT HOSP,DEPT SURG,SF-40620 JYVASKYLA,FINLAND

[5] UNIV HELSINKI,CENT HOSP,DEPT SURG 2,SF-00290 HELSINKI 29,FINLAND

[6] MEM UNIV NEWFOUNDLAND,FAC MED,ST JOHNS A1B 3V6,NEWFOUNDLAND,CANADA

[7] UNIV AUCKLAND,SCH MED,DEPT PATHOL,AUCKLAND,NEW ZEALAND

[8] MARSHFIELD MED RES FDN,MARSHFIELD,WI 54449

[9] JOHNS HOPKINS UNIV,SCH MED,DEPT ONCOL,BALTIMORE,MD 21205

[10] JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,BALTIMORE,MD 21205

[11] JOHNS HOPKINS UNIV,SCH MED,DEPT EPIDEMIOL,BALTIMORE,MD 21205

[12] JOHNS HOPKINS UNIV,SCH PUBL HLTH & HYG,BALTIMORE,MD 21218

[13] JOHNS HOPKINS UNIV HOSP,BALTIMORE,MD 21231

来源：

SCIENCE | 1993年 / 260卷 / 5109期

关键词：

D O I：

10.1126/science.8484120

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genetic linkage analysis was used to determine whether a specific chromosomal locus could be implicated in families with a history of early onset cancer but with no other unique features. Close linkage of disease to anonymous microsatellite markers on chromosome 2 was demonstrated in two large kindreds. The pairwise lod scores for linkage to marker D2S123 in these kindreds were 6.39 and 1.45 at zero recombination, and multipoint linkage with flanking markers resulted in lod scores of 6.47 and 6.01. These results prove the existence of a genetically determined predisposition to colorectal cancer that has important ramifications for understanding and preventing this disease.

引用

页码：810 / 812

页数：3

共 35 条

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