THE PSEUDORABIES VIRUS HOST-SHUTOFF HOMOLOG GENE - NUCLEOTIDE-SEQUENCE AND COMPARISON WITH ALPHAHERPESVIRUS PROTEIN COUNTERPARTS

被引：56

作者：

BERTHOMME, H

JACQUEMONT, B

EPSTEIN, A

机构：

[1] UNIV LYON 1,CTR GENET MOLEC & CELLULAIRE,CNRS,UMR 106,43 BLVD 11 NOVEMBRE 1918,F-69622 VILLEURBANNE,FRANCE

[2] UNIV LYON 1,FAC MED ALEXIS CARREL,NEUROVIROL MOLEC LAB,F-69372 LYON,FRANCE

来源：

VIROLOGY | 1993年 / 193卷 / 02期

关键词：

D O I：

10.1006/viro.1993.1221

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The virion host shutoff function (VHS) of many herpesviruses is required for inhibition of cellular gene expression in infected cells. This function corresponds to the UL41 open reading frame of herpes simplex virus type 1 (HSV-1) and homolog sequences have been found in other alphaherpesvirus, like HSV-2, Varicella-Zoster virus (VZV) and equine herpesvirus type 1 (EHV-1). In this work, we have cloned and sequenced a pseudorabies virus (PRV) gene which is homologous to the VHS genes of the other alphaherpesvirus. Sequence comparison between all deduced amino acid sequences indicates the presence of several conserved domains, separated by regions containing gaps or low conserved sequences. © 1993 Academic Press. All rights reserved.

引用

页码：1028 / 1032

页数：5

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