CORRELATION BETWEEN INVITRO MICROSOMAL-ENZYME ACTIVITY AND WHOLE ORGAN HEPATIC ELIMINATION KINETICS - ANALYSIS WITH A DISPERSION MODEL

被引：105

作者：

ROBERTS, MS

ROWLAND, M

机构：

[1] UNIV MANCHESTER,DEPT PHARM,MANCHESTER M13 9PL,LANCS,ENGLAND

[2] UNIV TASMANIA,SCH PHARM,HOBART,TAS 7001,AUSTRALIA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1986年 / 38卷 / 03期

关键词：

D O I：

10.1111/j.2042-7158.1986.tb04540.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：177 / 181

页数：5

共 33 条

[1] MODELS OF HEPATIC DRUG CLEARANCE - DISCRIMINATION BETWEEN THE WELL STIRRED AND PARALLEL-TUBE MODELS [J].

AHMAD, AB ;

BENNETT, PN ;

ROWLAND, M .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1983, 35 (04) :219-224

[2] HEPATIC ELIMINATION OF FLOWING SUBSTRATES - DISTRIBUTED MODEL [J].

BASS, L ;

ROBINSON, P ;

BRACKEN, AJ .

JOURNAL OF THEORETICAL BIOLOGY, 1978, 72 (01) :161-184

[3]

BASS L, 1976, Journal of Theoretical Biology, V61, P393, DOI 10.1016/0022-5193(76)90026-6

[4]

BILLINGS RE, 1977, BIOCH PHARM, V5, P516

[5] HEPATIC DRUG TRANSPORT IN THE RAT - A COMPARISON BETWEEN ISOLATED HEPATOCYTES, THE ISOLATED PERFUSED LIVER AND THE LIVER INVIVO [J].

BLOM, A ;

SCAF, AHJ ;

MEIJER, DKF .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (08) :1553-1565

[6]

BORG KO, 1974, ACTA PHARMACOL TOX, V35, P169

[7] CIRCULATORY PATHWAYS IN THE RAT LIVER AS REVEALED BY P-32 CHROMIC PHOSPHATE COLLOID UPTAKE IN THE ISOLATED PERFUSED LIVER PREPARATION [J].

BRAUER, RW ;

LEONG, GF ;

MCELROY, RF ;

HOLLOWAY, RJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1956, 184 (03) :593-598

[8]

COLLINS JM, 1978, DRUG METAB DISPOS, V6, P251

[9]

ERIKSON RR, 1982, J PHARM EXP THER, V220, P35

[10]

FREEMAN DS, 1977, J PHARM EXP THER, V203, P202

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