COPPER-METABOLISM - A FACTOR IN GESTATIONAL DIABETES

被引：15

作者：

LOVEN, A

ROMEM, Y

PELLY, IZ

HOLCBERG, G

AGAM, G

机构：

[1] BEN GURION UNIV NEGEV, SOROKA MED CTR, IL-84105 BEER SHEVA, ISRAEL

[2] BEN GURION UNIV NEGEV, FAC NAT SCI, DEPT GEOL, IL-84105 BEER SHEVA, ISRAEL

[3] BEN GURION UNIV NEGEV, FAC HLTH SCI, BIOCHEM LAB, IL-84105 BEER SHEVA, ISRAEL

[4] BEN GURION UNIV NEGEV, DEPT EXPTL PHYS, INST GENET, IL-84105 BEER SHEVA, ISRAEL

来源：

CLINICA CHIMICA ACTA | 1992年 / 213卷 / 1-3期

关键词：

GESTATIONAL DIABETES; SERUM COPPER AND CERULOPLASMIN; ERYTHROCYTE CUZN-SUPEROXIDE DISMUTASE;

D O I：

10.1016/0009-8981(92)90220-K

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The purpose of the present work was to investigate whether there is an involvement of copper metabolism in the mechanism of gestational diabetes mellitus. No statistically significant differences were found in serum copper and ceruloplasmin concentrations between healthy pregnant women and women with gestational diabetes mellitus. The activity of ceruloplasmin in women with gestational diabetes mellitus was slightly higher and its specific activity significantly raised. The CuZn superoxide dismutase activity was significantly increased (P < 0.05) in women with gestational diabetes mellitus, comparing the two groups by matched pairs according to age. The results indicate that oxidative stress may have a role in gestational diabetes mellitus and that reduced concentrations of copper are not the cause of this stress.

引用

页码：51 / 59

页数：9

共 36 条

[1] INCREASE IN THE GLUCOSYLATED FORM OF ERYTHROCYTE CU-ZN-SUPEROXIDE DISMUTASE IN DIABETES AND CLOSE ASSOCIATION OF THE NONENZYMATIC GLUCOSYLATION WITH THE ENZYME-ACTIVITY [J].