GENETIC-LINKAGE EVIDENCE FOR A FAMILIAL ALZHEIMERS-DISEASE LOCUS ON CHROMOSOME-14

被引：806

作者：

SCHELLENBERG, GD

BIRD, TD

WIJSMAN, EM

ORR, HT

ANDERSON, L

NEMENS, E

WHITE, JA

BONNYCASTLE, L

WEBER, JL

ALONSO, ME

POTTER, H

HESTON, LL

MARTIN, GM

机构：

[1] VET AFFAIRS MED CTR, DIV NEUROL, SEATTLE, WA 98108 USA

[2] UNIV WASHINGTON, DEPT MED, DIV MED GENET, SEATTLE, WA 98195 USA

[3] MARSHFIELD MED RES FDN, MARSHFIELD, WI 54449 USA

[4] NATL INST NEUROL & NEUROSURG, MEXICO CITY, MEXICO

[5] WASHINGTON INST MENTAL ILLNESS RES & TRAINING, DEPT PSYCHIAT, STEILACOOM, WA 98494 USA

[6] HARVARD UNIV, SCH MED, DEPT NEUROBIOL, BOSTON, MA 02115 USA

[7] UNIV MINNESOTA, DEPT LAB MED & PATHOL, MINNEAPOLIS, MN 55455 USA

[8] UNIV MINNESOTA, INST HUMAN GENET, MINNEAPOLIS, MN 55455 USA

[9] UNIV MINNESOTA, DEPT PSYCHIAT, MINNEAPOLIS, MN 55455 USA

[10] UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA

来源：

SCIENCE | 1992年 / 258卷 / 5082期

关键词：

D O I：

10.1126/science.1411576

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Linkage analysis was used to search the genome for chromosomal regions harboring familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant positive lod scores in early-onset non-Volga German kindreds; a Z(max) of 9.15 (theta = 0.01) was obtained with the marker D14S43 at 14q24.3. One early-onset family yielded a lod score of 4.89 (theta = 0.0). When no assumptions were made about age-dependent penetrance, significant results were still obtained (Z(max) = 5.94, theta = 0.0), despite the loss of power to detect linkage under these conditions. Results for the Volga German families were either negative or nonsignificant for markers in this region. Thus, evidence indicates a familial Alzheimer's disease locus on chromosome 14.

引用

页码：668 / 671

页数：4

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