ROLE OF THE SOURCE OF PHOSPHATE SALT IN IMPROVING THE MINERAL BALANCE OF PARENTERALLY FED LOW-BIRTH-WEIGHT INFANTS

被引:20
作者
CHESSEX, P
PINEAULT, M
BRISSON, G
DELVIN, EE
GLORIEUX, FH
机构
[1] UNIV MONTREAL, DEPT PEDIAT, MONTREAL H3C 3J7, QUEBEC, CANADA
[2] UNIV MONTREAL, DEPT PHARM, MONTREAL H3C 3J7, QUEBEC, CANADA
[3] UNIV MONTREAL, DEPT BIOCHIM, MONTREAL H3C 3J7, QUEBEC, CANADA
[4] SHRINERS HOSP CRIPPLED CHILDREN, MONTREAL, QUEBEC, CANADA
[5] MCGILL UNIV, MONTREAL H3A 2T5, QUEBEC, CANADA
基金
英国医学研究理事会;
关键词
D O I
10.1016/S0022-3476(05)82669-1
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Because the monobasic potassium phosphate salt (monobasic) improves the solubility of calcium and phosphorus in amino acid plus dextrose solutions, compared with the current mixtures of monobasic plus dibasic salts (dibasic), we tested the bioavailability and clinical effects of monobasic in 16 parenterally fed low birth weight infants at standard (n=8) and high levels (n=8) of mineral intakes. A constant infusion of macronutrients and vitamin D was provided in a crossover design of two four-day periods. With standard intakes of calcium (35 mg/kg/day, 0.9 mmol/kg/day) and phosphorus (30 mg/kg/day, 1mmol/kg/day), there was no difference between monobasic and dibasic regimens on balance data or plasma biochemical monitoring (calcium, phosphorus, pH, carbon dioxide pressure, base excess, 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D). With the use of the monobasic regimen, the mineral intakes were doubled without precipitation in the infusate: calcium, 70 mg/kg/day (1.8 mmol/kg/day), and phosphorus, 55 mg/kg/day (1.7 mmol/kg/day). This led to increased apparent retention of both calcium (63±5 mg/kg/day, 1.58±0.12 mmol/kg/day) and phosphorus (52±4 mg/kg/day, 1.67±0.14 mmol/kg/day) compared with that for standard levels of mineral intake. The improvement of calcium-phosphorus balance was accompanied by more severe calciuria (9±2 mg/kg/day, 0.2±0.05 mmol/kg/day) and by metabolic compensation for an increased acid load. In addition to the possibility of exceeding the buffering capacity of the infant, this relative acidosis could also be evidence of improved bone mineralization. © 1990 Mosby-Year Book, Inc.
引用
收藏
页码:765 / 772
页数:8
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