TETRAHYDROAMINOACRIDINE IN ALZHEIMERS-DISEASE

被引:14
作者
DAVIES, B
ANDREWES, D
STARGATT, R
AMES, D
TUCKWELL, V
DAVIS, S
机构
[1] Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Victoria, 3050, Clinical Sciences Building
[2] Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Victoria, 3050, Clinical Sciences Building
[3] Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Victoria, 3050, Clinical Sciences Building
[4] Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Clinical Sciences Building, Victoria
[5] Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Victoria, 3050, Clinical Sciences Building
[6] Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Victoria, 3050, Clinical Sciences Building
关键词
Alzheimer's disease; double blind; Tetrahydroaminoacridine; therapeutic trial;
D O I
10.1002/gps.930050508
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Tetrahydroaminoacridine (THA), a centrally acting anticholinesterase, was used in a two‐month, double‐blind, placebo‐controlled crossover trial to treat 10 patients meeting DSM‐III‐R criteria for dementia of the Alzheimer type. Eight patients continued to take THA for a further three months. Nausea was a frequent side‐effect. Five patients developed abnormal liver function tests; liver biopsies showed evidence of liver cell necrosis in three patients, a granulomatous reaction in one, and one recovered after reduction of THA dosage. During the trail, patients as a group showed a significantly better performance on one of 10 memory tests when taking THA as compared to placebo. One patient showed a marked clinical improvement, six showed some improvement, and three patients showed no improvement with the active treatment. The group of eight patients who completed a further three months of THA treatment showed a significant deterioration on two psychological test scores. Copyright © 1990 John Wiley & Sons, Ltd.
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页码:317 / 321
页数:5
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