COLCHICINE INTOXICATION - CLINICAL-PHARMACOLOGY, RISK-FACTORS, FEATURES, AND MANAGEMENT

被引：128

作者：

PUTTERMAN, C

BENCHETRIT, E

CARACO, Y

LEVY, M

机构：

[1] HADASSAH UNIV HOSP, DIV MED, RHEUMATOL UNIT, IL-91120 JERUSALEM, ISRAEL

[2] HADASSAH UNIV HOSP, FAMILIAL MEDITERRANEAN FEVER CLIN, IL-91120 JERUSALEM, ISRAEL

[3] HADASSAH UNIV HOSP, CLIN PHARMACOL UNIT, IL-91120 JERUSALEM, ISRAEL

来源：

SEMINARS IN ARTHRITIS AND RHEUMATISM | 1991年 / 21卷 / 03期

关键词：

COLCHICINE; COLCHICINE INTOXICATION; GOUT; FAMILIAL MEDITERRANEAN FEVER;

D O I：

10.1016/0049-0172(91)90003-I

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The use of colchicine for acute gouty arthritis dates to ancient times. In recent years, colchicine also has been used successfully for various other rheumatic and nonrheumatic conditions. Colchicine is a safe drug when used according to established therapeutic guidelines. However, toxicity can be considerable if ingested intentionally or if the recommended doses are exceeded. Colchicine intoxication is characterized by multiorgan involvement and by the poor prognosis associated with administration of large amounts of the drug. Therapy is basically supportive and symptomatic because of the rapid distribution and binding of colchicine to the affected tissues. Use of anticolchicine antibodies is a novel approach that has shown promise in experimental models. Important research questions pertain to the effect of liver and kidney disease on colchicine metabolism, use of colchicine levels in the diagnosis of intoxication and for prognostication, and application of immunotoxicotherapy for colchicine poisoning in humans. © 1991.

引用

页码：143 / 155

页数：13

共 98 条

[11] EFFECT OF COLCHICINE ON HUMAN OVULATION [J].