MECHANISMS OF SELF TOLERANCE

被引：40

作者：

KROEMER, G

MARTINEZA, C

机构：

[1] Guido Kroemer and Carlos Martínez-A. are, the Centro de Biología Molecular, CSIC, 28049 Madrid, Campus de Cantoblanco

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 10期

关键词：

D O I：

10.1016/0167-5699(92)90090-T

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The redundancy of biological systems minimizes the probability that isolated molecular and cellular defects entail deleterious consequences. This notion also applies to the establishment and maintenance of tolerance to self antigens. Thus, immune homeostasis is attributed to multiple distinct safety valves that are connected in series and intervene at defined control points of the life cycle of the developing lymphocyte to guarantee the physical elimination, functional inactivation, or regulated inhibition of self-reactive, potentially autoaggressive, B and T cells.

引用

页码：401 / 404

页数：4

共 45 条

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