A FACILE SYNTHESIS OF 2-SUBSTITUTED N-TERT-BUTOXYCARBONYL-N-METHYL-1,3-PROPANEDIAMINES, KEY INTERMEDIATES FOR THE PREPARATION OF TRIPLEX DNA-SPECIFIC INTERCALATORS

被引：13

作者：

STREKOWSKI, L ^{[1
]}

GULEVICH, Y ^{[1
]}

VANAKEN, K ^{[1
]}

WILSON, DW ^{[1
]}

FOX, KR ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,DEPT PHYSIOL & PHARMACOL,SOUTHAMPTON SO9 3TU,HANTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 02期

关键词：

D O I：

10.1016/0040-4039(94)02228-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-substituted 2-(2-naphthyl)quinolin-4-amines 4b,c are superior to other DNA intercalators reported to date in the ability to selectively stabilize triple helix DNA in the presence of duplex DNA. A facile synthesis of the title diamines 1 required for the preparation of 4 is based on a novel addition reaction of metallated tert-butyl N,N-dimethylcarbamate [Boc-N(Me)CH(2)M; 7, M=Li; 8, M=MgBr; 9, M=Cu(CN)ZnCl] with a nitroalkene.

引用

页码：225 / 228

页数：4

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