INEFFECTIVENESS OF ANALOGS OF D-GALACTAL AS COMPETITIVE INHIBITORS OF, AND SUBSTRATES FOR, BETA-D-GALACTOSIDASE FROM ESCHERICHIA-COLI

被引：28

作者：

DETTINGER, HM ^{[1
]}

KURZ, G ^{[1
]}

LEHMANN, J ^{[1
]}

机构：

[1] UNIV FREIBURG, CHEM LAB, D-7800 FREIBURG, FED REP GER

来源：

CARBOHYDRATE RESEARCH | 1979年 / 74卷 / SEP期

关键词：

D O I：

10.1016/S0008-6215(00)84784-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2,6-Anhydro-3-deoxy-aldehydo-D-lyxo-hept-2-enose (7) and 2,6-anhydro-3-deoxy-D-lyxo-hept-2-enitol (8) were synthesized as half-chair analogs of D-galactal (1). As 1 is a strong inhibitor of and a substrate for .beta.-D-galactosidase from E. coli, the same properties were expected for 7 and 8, but both were ineffective. This result, together with those of other authors, allows speculative conclusions on the tight binding of 1 to the enzyme only, when water or an alcohol is bound as a cosubstrate.

引用

页码：301 / 307

页数：7

共 9 条

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