CHIRAL MERCAPTOARYL-OXAZOLINES AS LIGANDS IN ASYMMETRIC CATALYSIS - ENANTIOSELECTIVE CU-CATALYZED 1,4-ADDITION OF GRIGNARD-REAGENTS TO ALPHA,BETA-UNSATURATED KETONES

被引：64

作者：

ZHOU, QL ^{[1
]}

PFALTZ, A ^{[1
]}

机构：

[1] UNIV BASEL,INST ORGAN CHEM,ST JOHANNS RING 19,CH-4056 BASEL,SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(00)61549-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper(I) thiolate complexes derived from chiral mercaptophenyl-oxazolines 3 have been studied as enantioselective catalysts for the 1,4-addition of Grignard reagents to alpha,beta-unsaturated ketones. For cyclic enones enantioselectivities increase in the sequence cyclopentenone (16-37% ee) < cyclohexenone (60-72% ee) < cycloheptenone (83-87% ee).

引用

页码：7725 / 7728

页数：4

共 26 条

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