MODE OF EXCRETION AND METABOLIC FATE OF POTASSIUM NAPHTHYL 2-35S-SULPHATE AND POTASSIUM 5,6,7,8-TETRAHYDRONAPHTHYL 2-35S-SULPHATE

The metabolic fates and modes of excretion of naphthyl 2-35S-sulphate and 5,6,7,8-tetrahydronaphthyl 2-35S-sulphate were investigated in the rat. Only small amounts of administered radioactivity were present in the bile of animals receiving the esters and in both cases the major proportion of the radioactive dose appeared in the urine. The bulk of the urinary radioactivity following naphthyl 2-35S-sulphate administration was identified as unchanged parent ester. Urines obtained from animals receiving 5,6,7,8-tetrahydronaphthyl 2-35S-sulphate also contained large quantities of unchanged parent ester. However, such urines also contained significant quantities of other radioactive components. The significance of the results is discussed in relation to the structural difference between naphthyl 2-35S-sulphate and 5,6,7,8-tetrahydro-naphthyl 2-35S-sulphate. © 1969.