MEASUREMENT OF GLUCOSE IN DIABETIC SUBJECTS USING NONINVASIVE TRANSDERMAL EXTRACTION

被引:141
作者
TAMADA, JA [1 ]
BOHANNON, NJV [1 ]
POTTS, RO [1 ]
机构
[1] MONTEAGLE MED CTR,SAN FRANCISCO,CA 94110
关键词
D O I
10.1038/nm1195-1198
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Results from the Diabetes Care and Complications Trial show that tight blood glucose control significantly reduces the long-term complications of diabetes mellitus(1). In that study, frequent self-testing of glucose and insulin administration resulted in a significant reduction in long-term complications. This protocol, however, also resulted in a threefold increase in the frequency of hypoglycaemic incidents. Currently, self-testing requires a drop of blood for each measurement. The pain and inconvenience of self-testing, along with the fear and danger of hypoglycaemia has led to poor patient acceptance of a tight control regimen, despite the clear long-term advantages. A continuously worn, noninvasive method to periodically measure glucose would provide a convenient and comfortable means of frequent self-testing(2,3). A continuously worn device could also alert the user of low glucose levels, thereby reducing the incidence of hypoglycaemia(4,5). Guy et al. demonstrated a noninvasive method to transport glucose through the skin using low-level electrical current(6,7). To provide a quantitative measurement, the flux of glucose extracted across the skin must correlate with serum glucose in a predictive manner. The results presented here show a quantitative relationship between serum and transdermally extracted glucose in diabetics.
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页码:1198 / 1201
页数:4
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