Effect of the thiol-oxidizing agent diamide on the growth of Escherichia coli

被引：37

作者：

Wax, Richard ^{[1
]}

Rosenberg, Eugene ^{[1
,2
]}

Kosower, Nechama S. ^{[1
,3
]}

Kosower, Edward M. ^{[1
,4
]}

机构：

[1] Weizmann Inst Sci, Dept Biochem Biol Ultrastruct & Biophys, IL-76100 Rehovot, Israel

[2] Univ Calif Los Angeles, Dept Bacteriol, Los Angeles, CA USA

[3] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[4] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11790 USA

来源：

JOURNAL OF BACTERIOLOGY | 1970年 / 101卷 / 03期

关键词：

D O I：

10.1128/JB.101.3.1092-1093.1970

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Oxidation of glutathione within Escherichia coli cells by diamide, (CH3)(2)NCON=NCON(CH3)(2), stops growth but does not cause cell death. Normal growth rates are resumed after periods which vary in length according to the diamide concentration. Consumption of excess reagent with added glutathione quickly reverses the inhibition. Another thiol-oxidizing agent, azoester, C6H5N=NCOOCH3, causes lysis.

引用

页码：1092 / 1093

页数：2

共 10 条

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