MUTAGENICITY OF VINYL-CHLORIDE IN MAN - COMPARISON OF CHROMOSOME-ABERRATIONS WITH MICRONUCLEUS AND SISTER-CHROMATID EXCHANGE FREQUENCIES

被引：26

作者：

FUCIC, A ^{[1
]}

HORVAT, D ^{[1
]}

DIMITROVIC, B ^{[1
]}

机构：

[1] VINILPLASTIKA MED DEPT, ZADAR, YUGOSLAVIA

来源：

MUTATION RESEARCH | 1990年 / 242卷 / 04期

关键词：

Chromosome aberration assay; Micronucleus assay; Sister-chromatid exchanges; Smokers'/non-smokers' human lymphocytes; Vinyl chloride;

D O I：

10.1016/0165-1218(90)90044-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mutagenic effects of vinyl chloride monomer in man were studied in the lymphocyte culture with 3 methods: the chromosome aberration assay, the micronucleus assay and the sister-chromatid exchange method. Compared with control, values obtained by these tests are increased in workers occupationally exposed to vinyl chloride. In relation to non-smokers, smokers exposed to vinyl chloride show significant increases in sister-chromatid exchange frequencies. The problem of correlating the results of the chromosome aberration assay with micronucleus and sister-chromatid exchange frequencies is discussed. © 1990.

引用

页码：265 / 270

页数：6