NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - N-[(BENZYLOXY)BENZYL]IMIDAZOLES AND RELATED-COMPOUNDS AS POTENT ANTIHYPERTENSIVES

被引：97

作者：

CARINI, DJ ^{[1
]}

DUNCIA, JV ^{[1
]}

JOHNSON, AL ^{[1
]}

CHIU, AT ^{[1
]}

PRICE, WA ^{[1
]}

WONG, PC ^{[1
]}

TIMMERMANS, PBMW ^{[1
]}

机构：

[1] DUPONT CO INC,DEPT MED PROD,CARDIOVASC PHARMACOL SECT,EXPTL STN,WILMINGTON,DE 19880

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 33卷 / 05期

关键词：

D O I：

10.1021/jm00167a008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of compounds has been synthesized and demonstrated to be antagonists of the angiotensin II (All) receptor. These compounds are structurally related to the N-(benzamidobenzyl)imidazoles and extend the scope of this new class of nonpeptide All antagonists. It has been found that the amide linkage (X = NHCO) in the N-(benzamidobenzyl)imidazoles can be replaced successfully by a variety of groups (X = single bond, O, S, CO, OCH2, CH=CH, NHCONH); linkers of 0-1 atoms in length are most effective. When administered intravenously to awake renal hypertensive rats, these compounds are potent antihypertensives. © 1990, American Chemical Society. All rights reserved.

引用

页码：1330 / 1336

页数：7

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