THERMODYNAMIC PERTURBATIONS OF MOLECULAR-SYSTEMS

被引：4

作者：

DEMETRIUS, L

机构：

[1] Museum of Comparative Zoology, Harvard University, Cambridge

来源：

JOURNAL OF CHEMICAL PHYSICS | 1992年 / 97卷 / 09期

关键词：

D O I：

10.1063/1.463670

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This note invokes thermodynamic perturbation theory to provide explicit expressions for the changes in free energy and entropy as a result of small variations in the structure of complex molecular systems. We use these perturbation methods to establish, under certain kinds of variations, correlations between the changes in free energy and the changes in entropy. The analytic results described in this note are intended to complement the procedures being implemented in J. Mol. Biol. 224, 771 (1992) to experimentally assess the effect of mutations on the stability of certain proteins.

引用

页码：6663 / 6665

页数：3

共 8 条

[1]

BROOKS CL, 1988, PROTEINS THEORETICAL

[2]

DEMETRIUS L, 1987, J CHEM PHYS, V87, P6936

[3]

DEMETRIUS L, 1922, UNPUB PROTEIN ENG

[4]

FERSHT A, 1985, ENZYME STRUCTURE MEC