MAPPING THE TRANSITION-STATE AND PATHWAY OF PROTEIN FOLDING BY PROTEIN ENGINEERING

被引：653

作者：

MATOUSCHEK, A ^{[1
]}

KELLIS, JT ^{[1
]}

SERRANO, L ^{[1
]}

FERSHT, AR ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT CHEM,MRC,PROT FUNCT & DESIGN UNIT,LENSFIELD RD,CAMBRIDGE CB2 1EW,ENGLAND

来源：

NATURE | 1989年 / 340卷 / 6229期

关键词：

D O I：

10.1038/340122a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：122 / 126

页数：5

共 21 条

[1] EFFECTS OF THE PHENYLALANINE-22-]LEUCINE, GLUTAMIC ACID-49-]METHIONINE, GLYCINE-234-]ASPARTIC ACID, AND GLYCINE-234-]LYSINE MUTATIONS ON THE FOLDING AND STABILITY OF THE ALPHA-SUBUNIT OF TRYPTOPHAN SYNTHASE FROM ESCHERICHIA-COLI
BEASTY, AM
HURLE, MR
MANZ, JT
STACKHOUSE, T
ONUFFER, JJ
MATTHEWS, CR
[J]. BIOCHEMISTRY, 1986, 25 (10) : 2965 - 2974
[2] LOW-TEMPERATURE UNFOLDING OF A MUTANT OF PHAGE-T4 LYSOZYME .2. KINETIC INVESTIGATIONS
CHEN, BL
BAASE, WA
SCHELLMAN, JA
[J]. BIOCHEMISTRY, 1989, 28 (02) : 691 - 699
[3] TOWARD A BETTER UNDERSTANDING OF PROTEIN FOLDING PATHWAYS
CREIGHTON, TE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (14) : 5082 - 5086
[4] Fersht A, 1985, ENZYME STRUCTURE MEC
[5] RELATIONSHIPS BETWEEN APPARENT BINDING-ENERGIES MEASURED IN SITE-DIRECTED MUTAGENESIS EXPERIMENTS AND ENERGETICS OF BINDING AND CATALYSIS
FERSHT, AR
[J]. BIOCHEMISTRY, 1988, 27 (05) : 1577 - 1580
[6] STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS - ANALYSIS OF USE OF BINDING-ENERGY BY LINEAR FREE-ENERGY RELATIONSHIPS
FERSHT, AR
LEATHERBARROW, RJ
WELLS, TNC
[J]. BIOCHEMISTRY, 1987, 26 (19) : 6030 - 6038
[7] DISSECTION OF THE STRUCTURE AND ACTIVITY OF THE TYROSYL-TRANSFER RNA-SYNTHETASE BY SITE-DIRECTED MUTAGENESIS
FERSHT, AR
[J]. BIOCHEMISTRY, 1987, 26 (25) : 8031 - 8037
[8] EFFECTS OF MULTIPLE REPLACEMENTS AT A SINGLE POSITION ON THE FOLDING AND STABILITY OF DIHYDROFOLATE-REDUCTASE FROM ESCHERICHIA-COLI
GARVEY, EP
MATTHEWS, CR
[J]. BIOCHEMISTRY, 1989, 28 (05) : 2083 - 2093
[9] MUTATIONAL ANALYSIS OF A PROTEIN-FOLDING PATHWAY
GOLDENBERG, DP
FRIEDEN, RW
HAACK, JA
MORRISON, TB
[J]. NATURE, 1989, 338 (6211) : 127 - 132
[10] CONTRIBUTION OF HYDROPHOBIC INTERACTIONS TO PROTEIN STABILITY
KELLIS, JT
NYBERG, K
SALI, D
FERSHT, AR
[J]. NATURE, 1988, 333 (6175) : 784 - 786

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