STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS - ANALYSIS OF USE OF BINDING-ENERGY BY LINEAR FREE-ENERGY RELATIONSHIPS

被引:146
作者
FERSHT, AR
LEATHERBARROW, RJ
WELLS, TNC
机构
关键词
D O I
10.1021/bi00393a013
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
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页码:6030 / 6038
页数:9
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共 17 条
  • [1] EFFICIENCY AND EVOLUTION OF ENZYME CATALYSIS
    ALBERY, WJ
    KNOWLES, JR
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1977, 16 (05): : 285 - 293
  • [2] CRYSTAL-STRUCTURES OF 2 FACTITIOUS MUTANTS OF TYROSYL-TRANSFER RNA-SYNTHETASE
    BROWN, KA
    VRIELINK, A
    BLOW, DM
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1986, 14 (06) : 1228 - 1229
  • [3] PROBING STERIC AND HYDROPHOBIC EFFECTS ON ENZYME-SUBSTRATE INTERACTIONS BY PROTEIN ENGINEERING
    ESTELL, DA
    GRAYCAR, TP
    MILLER, JV
    POWERS, DB
    BURNIER, JP
    NG, PG
    WELLS, JA
    [J]. SCIENCE, 1986, 233 (4764) : 659 - 663
  • [4] HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING
    FERSHT, AR
    SHI, JP
    KNILLJONES, J
    LOWE, DM
    WILKINSON, AJ
    BLOW, DM
    BRICK, P
    CARTER, P
    WAYE, MMY
    WINTER, G
    [J]. NATURE, 1985, 314 (6008) : 235 - 238
  • [5] QUANTITATIVE-ANALYSIS OF STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS BY LINEAR FREE-ENERGY RELATIONSHIPS
    FERSHT, AR
    LEATHERBARROW, RJ
    WELLS, TNC
    [J]. NATURE, 1986, 322 (6076) : 284 - 286
  • [6] BINDING-ENERGY AND CATALYSIS - A LESSON FROM PROTEIN ENGINEERING OF THE TYROSYL-TRANSFER RNA-SYNTHETASE
    FERSHT, AR
    LEATHERBARROW, RJ
    WELLS, TNC
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1986, 11 (08) : 321 - 325
  • [7] ANALYSIS OF ENZYME STRUCTURE AND ACTIVITY BY PROTEIN ENGINEERING
    FERSHT, AR
    SHI, JP
    WILKINSON, AJ
    BLOW, DM
    CARTER, P
    WAYE, MMY
    WINTER, GP
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1984, 23 (07): : 467 - 473
  • [8] FOSTER RJ, 1961, J BIOL CHEM, V236, P2461
  • [9] INTERNAL THERMODYNAMICS OF POSITION 51 MUTANTS AND NATURAL VARIANTS OF TYROSYL-TRANSFER RNA-SYNTHETASE
    HO, CK
    FERSHT, AR
    [J]. BIOCHEMISTRY, 1986, 25 (08) : 1891 - 1897
  • [10] JENCKS WP, 1985, CHEM REV, V85, P511, DOI 10.1021/cr00070a001