RELATIONSHIPS BETWEEN APPARENT BINDING-ENERGIES MEASURED IN SITE-DIRECTED MUTAGENESIS EXPERIMENTS AND ENERGETICS OF BINDING AND CATALYSIS

被引：189

作者：

FERSHT, AR

机构：

来源：

BIOCHEMISTRY | 1988年 / 27卷 / 05期

关键词：

D O I：

10.1021/bi00405a027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1577 / 1580

页数：4

共 13 条

[1] CRYSTAL-STRUCTURE OF A DELETION MUTANT OF A TYROSYL-TRANSFER RNA-SYNTHETASE COMPLEXED WITH TYROSINE [J].

BRICK, P ;

BLOW, DM .

JOURNAL OF MOLECULAR BIOLOGY, 1987, 194 (02) :287-297

[2]

Fersht A, 1985, ENZYME STRUCTURE MEC

[3] HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING [J].

FERSHT, AR ;

SHI, JP ;

KNILLJONES, J ;

LOWE, DM ;

WILKINSON, AJ ;

BLOW, DM ;

BRICK, P ;

CARTER, P ;

WAYE, MMY ;

WINTER, G .

NATURE, 1985, 314 (6008) :235-238

[4] THE HYDROGEN-BOND IN MOLECULAR RECOGNITION [J].

FERSHT, AR .

TRENDS IN BIOCHEMICAL SCIENCES, 1987, 12 (08) :301-304

[5] RECONSTRUCTION BY SITE-DIRECTED MUTAGENESIS OF THE TRANSITION-STATE FOR THE ACTIVATION OF TYROSINE BY THE TYROSYL-TRANSFER RNA-SYNTHETASE - A MOBILE LOOP ENVELOPES THE TRANSITION-STATE IN AN INDUCED-FIT MECHANISM [J].

FERSHT, AR ;

KNILLJONES, JW ;

BEDOUELLE, H ;

WINTER, G .

BIOCHEMISTRY, 1988, 27 (05) :1581-1587

[6] BINDING-ENERGY AND CATALYSIS - A LESSON FROM PROTEIN ENGINEERING OF THE TYROSYL-TRANSFER RNA-SYNTHETASE [J].

FERSHT, AR ;

LEATHERBARROW, RJ ;

WELLS, TNC .

TRENDS IN BIOCHEMICAL SCIENCES, 1986, 11 (08) :321-325

[7] INTERNAL THERMODYNAMICS OF POSITION 51 MUTANTS AND NATURAL VARIANTS OF TYROSYL-TRANSFER RNA-SYNTHETASE [J].

HO, CK ;

FERSHT, AR .

BIOCHEMISTRY, 1986, 25 (08) :1891-1897

[8] ON THE ATTRIBUTION AND ADDITIVITY OF BINDING-ENERGIES [J].

JENCKS, WP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (07) :4046-4050

[9] TRANSITION-STATE STABILIZATION IN THE MECHANISM OF TYROSYL-TRANSFER RNA-SYNTHETASE REVEALED BY PROTEIN ENGINEERING [J].

LEATHERBARROW, RJ ;

FERSHT, AR ;

WINTER, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (23) :7840-7844

[10] STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS - CHARACTERIZATION OF DISRUPTIVE DELETIONS IN THE ALPHA-AMMONIUM GROUP BINDING-SITE OF TYROSYL-TRANSFER RNA-SYNTHETASE [J].

LOWE, DM ;

WINTER, G ;

FERSHT, AR .

BIOCHEMISTRY, 1987, 26 (19) :6038-6043

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