RECONSTRUCTION BY SITE-DIRECTED MUTAGENESIS OF THE TRANSITION-STATE FOR THE ACTIVATION OF TYROSINE BY THE TYROSYL-TRANSFER RNA-SYNTHETASE - A MOBILE LOOP ENVELOPES THE TRANSITION-STATE IN AN INDUCED-FIT MECHANISM

被引：157

作者：

FERSHT, AR ^{[1
]}

KNILLJONES, JW ^{[1
]}

BEDOUELLE, H ^{[1
]}

WINTER, G ^{[1
]}

机构：

[1] MRC,MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

BIOCHEMISTRY | 1988年 / 27卷 / 05期

关键词：

D O I：

10.1021/bi00405a028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1581 / 1587

页数：7

共 25 条

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[2] A MODEL OF SYNTHETASE TRANSFER-RNA INTERACTION AS DEDUCED BY PROTEIN ENGINEERING
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[3] CRYSTAL-STRUCTURE OF A DELETION MUTANT OF A TYROSYL-TRANSFER RNA-SYNTHETASE COMPLEXED WITH TYROSINE
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BLOW, DM
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1987, 194 (02) : 287 - 297
[4] STRUCTURE OF A MUTANT OF TYROSYL-TRANSFER RNA-SYNTHETASE WITH ENHANCED CATALYTIC PROPERTIES
BROWN, KA
BRICK, P
BLOW, DM
[J]. NATURE, 1987, 326 (6111) : 416 - 418
[5] IMPROVED OLIGONUCLEOTIDE SITE-DIRECTED MUTAGENESIS USING M13 VECTORS
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BEDOUELLE, H
WINTER, G
[J]. NUCLEIC ACIDS RESEARCH, 1985, 13 (12) : 4431 - 4443
[6] CARTER PJ, 1984, CELL CAMBRIDGE, V38, P834
[7] DEMONSTRATION OF 2 ACTIVE-SITES ON A MONOMERIC AMINOACYL-TRANSFER-RNA SYNTHETASE - POSSIBLE ROLES OF NEGATIVE COOPERATIVITY AND HALF-OF-SITES REACTIVITY IN OLIGOMERIC ENZYMES
FERSHT, AR
[J]. BIOCHEMISTRY, 1975, 14 (01) : 5 - 12
[8] RELATIONSHIPS BETWEEN APPARENT BINDING-ENERGIES MEASURED IN SITE-DIRECTED MUTAGENESIS EXPERIMENTS AND ENERGETICS OF BINDING AND CATALYSIS
FERSHT, AR
[J]. BIOCHEMISTRY, 1988, 27 (05) : 1577 - 1580
[9] LIGAND-BINDING AND ENZYMIC CATALYSIS COUPLED THROUGH SUBUNITS IN TYROSYL-TRANSFER-RNA SYNTHETASE
FERSHT, AR
MULVEY, RS
KOCH, GLE
[J]. BIOCHEMISTRY, 1975, 14 (01) : 13 - 18
[10] STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS - ANALYSIS OF USE OF BINDING-ENERGY BY LINEAR FREE-ENERGY RELATIONSHIPS
FERSHT, AR
LEATHERBARROW, RJ
WELLS, TNC
[J]. BIOCHEMISTRY, 1987, 26 (19) : 6030 - 6038

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